Experimental Brain Research

, Volume 13, Issue 2, pp 140–158

Pain reactivity of monkeys after lesions to the dorsal and lateral columns of the spinal cord

  • C. J. VierckJr.
  • D. M. Hamilton
  • J. I. Thornby
Article

DOI: 10.1007/BF00234083

Cite this article as:
Vierck, C.J., Hamilton, D.M. & Thornby, J.I. Exp Brain Res (1971) 13: 140. doi:10.1007/BF00234083

Summary

Macaca speciosa monkeys were trained to escape electrical stimulation of either hindlimb, and they were given the alternative of witholding the response for 10 sec to receive food reward. The force, latency and threshold of escape responses were measured as a function of stimulation intensity before and after lesions of the spinal cord. The stimulus range was set so that pain was certainly evoked by some portion of the intensities above escape threshold, and it was inferred that pain reactivity was altered if the force or latency curves or both were shifted by a lesion. Ipsilateral dorsal column lesions decreased pain reactivity as revealed by higher latencies and lower forces of escape responses. Thresholds were generally unaffected. Ipsilateral lesions of the dorsolateral column produced hyperesthesia, or reduced latencies and increased forces. Thresholds were again unaffected. Contralateral lesions of the lateral column elevated thresholds, and this effect was magnified by inclusion of the dorsal columns in the lesion.

Key Words

Pain Somesthesis Dorsal columns Spinal cord 

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • C. J. VierckJr.
    • 1
  • D. M. Hamilton
    • 1
  • J. I. Thornby
    • 1
  1. 1.Department of Neuroscience and Center for Neurobiological SciencesUniversity of Florida College of MedicineGainesvilleUSA

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