Experimental Brain Research

, Volume 107, Issue 3, pp 479–485 | Cite as

The role of the dorsolateral prefrontal cortex in implicit procedural learning

  • Alvaro Pascual-Leone
  • Eric M. Wassermann
  • Jordan Grafman
  • Mark Hallett
Research Article

Abstract

We studied the role of the dorsolateral prefrontal cortex in procedural learning. Normal subjects completed several blocks of a serial reaction time task using only one hand without or with concurrent non-invasive repetitive transcranial magnetic stimulation. To disrupt their function transiently, stimulation was applied at low intensity over the supplementary motor area or over the dorsolateral prefrontal cortex contralateral or ipsilateral to the hand used for the test. Stimulation to the contralateral dorsolateral prefrontal cortex markedly impaired procedural implicit learning, as documented by the lack of significant change in response times during the task. Stimulation over the other areas did not interfere with learning. These results support the notion of a critical role of contralateral dorsolateral prefrontal structures in learning of motor sequences.

Key words

Transcranial magnetic stimulation Learning and memory Cortical physiology Human 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Alvaro Pascual-Leone
    • 1
    • 2
  • Eric M. Wassermann
    • 1
  • Jordan Grafman
    • 3
  • Mark Hallett
    • 1
  1. 1.Human Motor Control Section, Medical Neurology BranchNational Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA
  2. 2.Consejo Superior Investigaciones Cientificas, Unidad de Neurobiología, Departamento de FisiologíaUniversidad de ValenciaValenciaSpain
  3. 3.Cognitive Neuroscience Section, Medical Neurology BranchNational Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA

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