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Experimental Brain Research

, Volume 111, Issue 1, pp 149–152 | Cite as

Response of guinea pig vestibular nucleus neurons to clicks

  • Toshihisa Murofushi
  • Ian S. Curthoys
  • Darrin P. Gilchrist
Research Note

Abstract

Responses of single neurons in the vestibular nuclei to clicks were studied by extracellular recording in anaesthetised guinea pigs. Eighty-four neurons in the ipsilateral vestibular nuclei were activated with an average latency of 1.75±0.30 ms, which is about 0.9 ms longer than the mean latency of activation of click-sensitive vestibular afferents to intense clicks. The threshold of clicks for evoking the response of these neurons was around 70 dB above the auditory brainstem response threshold. Earlier studies have indicated that click-sensitive vestibular afferents are tilt-sensitive and likely to originate from saccular receptors, and in the present study nine of the click-sensitive vestibular nucleus neurons were tilt-sensitive, suggesting that these central neurons receive monosynaptic input from the corresponding saccular afferents. Recording sites were marked by means of iontophoretic injection of FCF green dye; they were located in the lateral portion of the descending vestibular nucleus and the caudal and ventral regions of the lateral vestibular nucleus.

Key words

Sound Saccule Otolith Vestibular nucleus Vestibulo-collic 

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References

  1. Brown MC, Liberman MC, Benson TE, Ryugo DK (1988) Brainstem branches from olivocochlear axons in cats and rodents. J Comp Neurol 278:591–603Google Scholar
  2. Burian M, Gstoettner W (1988) Projection of primary vestibular afferent fibres to the cochlear nucleus in the guinea pig. Neurosci Lett 84:13–17Google Scholar
  3. Cazals Y, Aran J-M, Erre J-P, Guilhaume A (1980) Acoustic responses after total destruction of the cochlear receptor: brainstem and auditory cortex. Science 210:83–86Google Scholar
  4. Cazals Y, Erre J-P, Aurousseau C (1987) Eighth nerve auditory evoked responses recorded at the base of the vestibular nucleus in the guinea pig. Hear Res 31:93–98Google Scholar
  5. Colebatch JG, Halmagyi GM, Skuse NF (1994) Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 57:190–197Google Scholar
  6. Didier A, Cazals Y (1989) Acoustic responses recorded from the saccular bundle on the eighth nerve of the guinea pig. Hear Res 37:123–128Google Scholar
  7. Didier A, Cazals Y, Aurousseau C (1987) Brainstem connections of the anterior and posterior parts of the saccule in the guinea pig. Acta Otolaryngol (Stockh) 104:385–391Google Scholar
  8. Gacek RR (1969) The course and central termination of first order neurons supplying vestibular endorgans in the cat. Acta Otolaryngol (Stockh) Suppl.254:1–66Google Scholar
  9. Gstoettner W, Burian M (1987) Vestibular nuclear complex in the guinea pig: a cytoarchitectonic study and map in three planes. J Comp Neurol 257:176–188Google Scholar
  10. Gstoettner W, Burian M, Cartellieri M (1992) Central projections from singular parts of the vestibular labyrinth in the guinea pig. Acta Otolaryngol (Stockh) 112:486–495Google Scholar
  11. Halmagyi GM, Colebatch JG (1995) Vestibular evoked myogenic potentials in the sternomastoid muscle are not of lateral canal origin. Acta Otolaryngol (Stockh) Suppl 520:1–3Google Scholar
  12. Hwang JC, Poon WF (1975) An electrophysiological study of the sacculo-ocular pathways in cats. Jpn J Physiol 25:241–251Google Scholar
  13. Ito J, Takahashi H, Matsuoka I, Takatani T, Sasa M, Takatori S (1983) Vestibular efferent fibers to ampulla of anterior, lateral and posterior canals in cats. Brain Res 259:293–297Google Scholar
  14. Kevetter GA, Perachio AA (1989) Projections from the sacculus to the cochlear nuclei in the mongolian gerbil. Brain Behav Evol 34:193–200Google Scholar
  15. Liberman MC, Brown MC (1986) Physiology and anatomy of single olivocochlear neurons in the cat. Hear Res 24:17–36CrossRefPubMedGoogle Scholar
  16. McCue MP, Guinan JJ Jr (1994) Acoustically responsive fibers in the vestibular nerve of the cat. J Neurosci 14:6058–6070Google Scholar
  17. McCue MP, Guinan JJ Jr (1995) Spontaneous activity and frequency selectivity of acoustically responsive vestibular afferents in the cat. J Neurophysiol 74:1563–1572Google Scholar
  18. Murofushi T, Kaga K, Asakage T (1994) Temporary latency shifts in auditory evoked potentials by injection of lidocaine in the rat. Hear Res 76:53–59Google Scholar
  19. Murofushi T, Curthoys IS, Topple AN, Colebatch JG, Halmagyi GM (1995) Responses of guinea pig primary vestibular neurons to clicks. Exp Brain Res 103:174–178Google Scholar
  20. Murofushi T, Halmagyi GM, Yavor RA, Colebatch JG (1996) Absent vestibular evoked myogenic potentials in vestibular neuritis: an indicator of involvement of the inferior vestibular nerve? Arch Otolaryngol Head Neck Surg (in press)Google Scholar
  21. Rhode WS, Smith PH (1986) Encoding timing and intensity in the ventral cochlear nucleus of the cat. J Neurophysiol 56:261–286Google Scholar
  22. Sato H, Imagawa M, Sasaki M, Endo K, Ikegami H, Isu N, Uchino Y (1995) Differences between the utricular activated and saccular activated second order vestibulospinal neurons in cats. Soc Neurosci Abstr 21:1914Google Scholar
  23. Thomas RC, Wilson VJ (1965) Precise localization of Renshaw cells with a new marking technique. Nature 206:211–213Google Scholar
  24. Tickle DR, Schneider GE (1982) Projection of the auditory nerve to the medial vestibular nucleus. Neurosci Lett 28:1–7Google Scholar
  25. Uchino Y, Sato H, Imagawa M, Sasaki M, Ikegami M (1994) The sacculo-neck reflex arc of the decerebrate cat. In: Taguchi K, Igarashi M, Mori S (eds) Vestibular and neural front. Elsevier, Amsterdam, pp 517–520Google Scholar
  26. Wilson VJ, Boyle R, Fukushima K, Rose PK, Shinoda Y, Sugiuchi Y, Uchino Y (1995) The vestibulocollic reflex. J Vestib Res 5:147–170Google Scholar
  27. Young ED, Fernández C, Goldberg JM (1977) Responses of squirrel monkey vestibular neurons to audio-frequency sound and head vibration. Acta Otolaryngol (Stockh) 84:352–360Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Toshihisa Murofushi
    • 1
    • 2
  • Ian S. Curthoys
    • 1
  • Darrin P. Gilchrist
    • 1
  1. 1.Department of PsychologyUniversity of SydneyAustralia
  2. 2.Neuro-otology DepartmentRoyal Prince Alfred HospitalSydneyAustralia

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