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Cell and Tissue Research

, Volume 255, Issue 1, pp 149–153 | Cite as

Renin-positive granulated Goormaghtigh cells

Immunohistochemical and electron-microscopic studies on biopsies from patients with pseudo-Bartter syndrome
  • J. A. Christensen
  • A. Bohle
  • E. Mikeler
  • R. Taugner
Article

Summary

It is difficult to distinguish between Goormaghtigh cells (G-cells) and media cells of the glomerular arterioles at the border of the Goormaghtigh cell field. Consequently, it has been unclear whether renin-positive G-cells are normally present and also whether renin-producing cells are recruited from the pool of renin-negative G-cells upon stimulation of the renin-angiotensin system (RAS). In the present study, immunohistochemical and electron-microscopic experiments have been carried out on serially sectioned kidney biopsies from four patients with pseudo-Bartter syndrome. The results strongly suggest that with longlasting stimulation of the RAS all renin-negative (“secretory resting”) G-cells are ultimately converted into renin-producing granular cells.

Key words

Goormaghtigh cells Granular cells Renin synthesis Juxtaglomerular apparatus Pseudo-Bartter syndrome Human 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. A. Christensen
    • 1
  • A. Bohle
    • 2
  • E. Mikeler
    • 2
  • R. Taugner
    • 3
  1. 1.The Gade Institute, Department of PathologyUniversity of BergenBergenNorway
  2. 2.The Institute of PathologyUniversity of TübingenTübingenGermany
  3. 3.Institute of PhysiologyUniversity of HeidelbergHeidelbergGermany

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