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Experimental Brain Research

, Volume 98, Issue 2, pp 200–212 | Cite as

Vestibular nucleus projections to nucleus tractus solitarius and the dorsal motor nucleus of the vagus nerve: potential substrates for vestibulo-autonomic interactions

  • Carey D. Balaban
  • Gennady Beryozkin
Original Paper

Abstract

Autonomic effects of vestibular stimulation are important components of phenomena as diverse as acute vestibular dysfunction and motion sickness. How ever, the organization of neural circuits mediating these responses is poorly understood. This study presents evidence for direct vestibular nucleus projections to brain stem regions that mediate autonomic function. One group of albino rabbits received injections of Phaseolus vulgaris leucoagglutinin into the vestibular nuclei. The tracer was visualized immunocytochemically with standard techniques. Anterogradely labeled axons from the caudal medial vestibular nucleus (cMVN) and inferior vestibular nucleus (IVN) could be traced bilaterally to nucleus tractus solitarius (NTS). Fewer axons ended near the somata of neurons in the dorsal motor nucleus of the vagus nerve (DMX). A second group of rabbits received pressure or iontophoretic injections of cholera toxin B-HRP or Fluoro-Gold into a region including NTS and DMX. Retrogradely labeled neurons were observed bilaterally in the caudal half of cMVN and ipsilaterally in IVN. The labeled somata were small and they tended to occupy the center of cMVN in transverse sections. These previously unreported vestibular nucleus projections to NTS and DMX are a potential substrate for vestibular influences on autonomic function. In particular, they may contribute to both cardiovascular control during head movements (e.g., orthostatic reflexes) and autonomic manifestions of vestibular dysfunction, motion sickness and exposure to altered gravitational environments.

Key words

Vestibular nuclei Autonomic nervous system Nucleus tractus solitarius Dorsal motor vagal nucleus Rabbit 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Carey D. Balaban
    • 1
  • Gennady Beryozkin
    • 1
  1. 1.Department of OtolaryngologyUniversity of Pittsburgh, The Eye and Ear InstitutePittsburghUSA

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