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Experimental Brain Research

, Volume 80, Issue 3, pp 626–630 | Cite as

GABA-induced remote inactivation reveals cross-orientation inhibition in the cat striate cortex

  • U. T. Eysel
  • J. M. Crook
  • H. F. Machemer
Research Note

Summary

We investigated the contributions of lateral intracortical connections to the orientation tuning of area 17 cells using micro-iontophoresis of the inhibitory transmitter gamma-aminobutyric acid (GABA) to inactivate small cortical sites in the vicinity of a recorded cell. GABA was ejected from an array of micropipettes each with an average horizontal distance of 500 μm from the recording site. Of 54 cells tested, 33 showed a reduction and 3 a loss of orientation selectivity due to an increase in responses to non-optimal orientations during GABA inactivation. The response to the optimal orientation remained constant in more than half of the cells and increased or decreased in others. Given that a complete cycle of orientations occupies a tangential distance of 1000 μm, the observed broadening of orientation tuning is presumably due to GABA-mediated inactivation of inhibitory interneurones with different preferred orientations from those of their target cell.

Key words

Visual cortex Orientation tuning Inhibition Local inactivation Cat 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • U. T. Eysel
    • 1
  • J. M. Crook
    • 1
  • H. F. Machemer
    • 1
  1. 1.Abteilung Neurophysiologie, Medizinische FakultätRuhr-Universität BochumBochumFederal Republic of Germany

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