Cell and Tissue Research

, Volume 185, Issue 1, pp 63–68 | Cite as

Alpha-1-antitrypsin immunoreactivity in islet cells of adult human pancreas

  • M. B. Ray
  • V. J. Desmet
  • W. Gepts


Alpha-1-antitrypsin immunoreactivity was demonstrated by immunofluorescence technique in the peripheral islet cells of all ten normal adult human pancreata examined; normal adult human liver was negative. The specificity of the reactions was confirmed by applying various control tests including absorption of the specific antisera with purified alpha-1-antitryspin, inhibition and blocking tests and by ensuring the monospecificity of the antisera used. The findings suggest that the pancreatic islet may be an additional source of alpha-1-antitryspin.

Key words

Pancreas (Human) Islet cells Alpha-1-antitrypsin Immunofluorescence 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • M. B. Ray
    • 1
  • V. J. Desmet
    • 1
  • W. Gepts
    • 2
  1. 1.Departement Medische Navorsing, Academisch Ziekenhuis Sint RafaëlLaboratorium voor Histochemie en CytochemieLeuvenBelgium
  2. 2.Laboratorium voor Anatomopathologie Universitair Ziekenhuis BrugmanBrusselBelgium

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