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Cell and Tissue Research

, Volume 254, Issue 2, pp 449–454 | Cite as

Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice

  • Andreas Cerny
  • Rolf M. Zinkernagel
  • Peter Groscurth
Article

Summary

We have studied follicular dendritic cells (FDC) in lymph nodes of normal and thymus dysgeneic nude mice depleted of B-cells by chronic treatment with anti-IgM antibodies. We found that B cell depletion was accompanied by the absence of mature FDC as defined morphologically at the ultrastructural level. Only precursor FDC (p-FDC) could be demonstrated. Upon release of B-cell suppression, the repopulation of lymph nodes with B-cells was associated with the reappearance of fully differentiated FDC in primary follicles of nude mice and in secondary follicles of T-cell competent mice. We conclude that mature B-cells and/or B-cell products are required for the development of mature follicular dendritic cells in the mouse lymph node.

Key words

Follicular dendritic cells Lymph nodes Electron microscopy Nude mice 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Andreas Cerny
    • 1
  • Rolf M. Zinkernagel
    • 1
  • Peter Groscurth
    • 2
  1. 1.Department of Experimental PathologyInstitute of Pathology, University HospitalZürichSwitzerland
  2. 2.Institute of Anatomy, Division of Cell Biology, University of Zürich-IrchelZürichSwitzerland

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