Cell and Tissue Research

, Volume 193, Issue 3, pp 413–422 | Cite as

Immunologie localization of α- and β-endorphins and β-lipotropin in corticotropic cells of the normal and anencephalic fetal pituitaries

  • M. Bégeot
  • M. P. Dubois
  • P. M. Dubois


The use of antibodies to α-(17–39) ACTH, β-LPH, and α- and β-endorphins has enabled the detection of immunoreactive cells as early as the eigth week of fetal life. Immunoreactive cells are located in the anterior and intermediate lobes of the pituitary gland in normal human fetuses. The same cells reacted with different antisera used in the present study. No immunoreactive cells were observed in the posterior lobe. The specificity of the immunocytological reaction has been controlled. In seven anencephalic fetuses, the presence of immunoreactive cells suggests that ACTH and β-LPH can originate from a common precursor and are synthesized independent of the hypothalamus.

Key words

ACTH β-LPH α- and β-endorphins Pituitary gland Immunocytology Human fetus Anencephaly 

List of Abbreviations










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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • M. Bégeot
    • 1
  • M. P. Dubois
    • 2
  • P. M. Dubois
    • 1
  1. 1.Faculté de Médecine Lyon-SudLaboratoire d'Histologie et EmbryologieOullinsFrance
  2. 2.Station de Physiologie de la Reproduction, INRANouzillyFrance

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