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Springer Seminars in Immunopathology

, Volume 12, Issue 4, pp 415–428 | Cite as

Histamine-releasing factors and heterogeneity of IgE

  • Susan M. MacDonald
  • Lawrence M. Lichtenstein
Article

Abstract

The duration and severity of the allergic response are variable. Even though antigens are rapidly cleared from the individual, an acute allergic response is frequently followed by a recrudescence of symptoms hours or even days after the initial exposure. Experimentally, the cellular infiltrates and mediators released during this late response resemble those associated with chronic inflammatory disease. Although basophils are present in this late reaction, the stimuli for their activation remain unknown. A heterogeneous group of unique cytokines called histamine-releasing factors (HRF), discovered over a decade ago, may well play a role in stimulating basophils during this late-phase reaction. These factors have been reported from a variety of cell sources including alveolar macrophages, platelets, vascular endothelial cells, B and T lymphocytes, mononuclear cell cultures, the U937 monocyte/macrophage-like cell line and the RPMI 8866 B cell line. These ubiquitous factors cause non-cytotoxic, calcium-dependent mediator release from human basophils in vitro and are also present and active in vivo. Purification attempts have revealed that HRF exists in at least three forms, based on molecular weight. In our hands, the mechanism of mediator release by one of the forms of HRF is IgE dependent. Since only about 50% of allergic donors' basophils respond to HRF, a heretofore unappreciated heterogeneity of IgE was revealed. The presence of HRF has been shown to correlate with severity of allergic disease in children with food allergies, with symptoms in the late-phase response in adults and with severity of the allergic response to an inhaled antigen. Thus, the study of HRF has evolved over the last decade and may lead to better understanding of the complex allergic response.

Keywords

Late Response Food Allergy Alveolar Macrophage Vascular Endothelial Cell Allergic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Alam R, Rozniecki J (1985) A mononuclear cell-derived histamine-releasing factor in asthmatic patients. Allergy 40: 124Google Scholar
  2. 2.
    Alam R, Rozniecki J, Salmaj K (1984) A mononuclear cell-derived histamine-releasing factor (HRF) in asthmatic patients. Histamine release from basophils in vitro. Ann Allergy 53: 66Google Scholar
  3. 3.
    Alam R, Kuna P, Rozniecki J, Kuzminska B (1987) The magnitude of the spontaneous production of histamine-releasing factor (HRF) by lymphocytes in vitro correlates with the state of bronchial hyperreactivity in patients with asthma. J Allergy Clin Immunol 79: 103Google Scholar
  4. 4.
    Alam R, Grant JA, Lett-Brown MA (1988) Identification of a histamine-release inhibitory factor produced by human mononuclear cells in vitro. J Clin Invest 82: 2056Google Scholar
  5. 5.
    Alam R, Welter JB, Forsythe PA, Lett-Brown MA, Grant JA (1989) Comparative effect of recombinant IL-1, -2, -3, -4, and -6, IFN-γ, granulocyte macrophage-colony-stimulating factor, tumor necrosis factor-α and histamine-releasing factors on the secretion of histamine from basophils. J Immunol 142: 3431Google Scholar
  6. 6.
    Baenzinger J, Kornfeld S (1974) Structure of the carbohydrate units of IgE immunoglobulin. J Biol Chem 249: 1889Google Scholar
  7. 7.
    Baeza ML, Haak-Frendscho M, Satnick S, Kaplan AP (1988) Responsiveness to human mononuclear cell-derived histamine-releasing factor. Studies of allergic status and the role of IgE. J Immunol 141: 2688Google Scholar
  8. 8.
    Baeza ML, Reddigari S, Haak-Frendscho M, Kaplan AP (1989) Purification and further characterization of human mononuclear cell histamine-releasing factor. J Clin Invest 83: 1204Google Scholar
  9. 9.
    Baeza ML, Reddigari S, Kornfeld D, Gorevic P, Kaplan AP (1989) Histamine-releasing factor(s) (HRF) from human mononuclear cells: further characterization and preparation of monoclonal antibodies. J Allergy Clin Immunol 83: 237Google Scholar
  10. 10.
    Baeza ML, Reddigari S, Kornfeld D, Ramani N, Smith EM, Hossler PA, Castor CW, Gorevic PG, Kaplan AP (1989) Relationship of one form of human histamine-releasing factor (HRF) to connective tissue activating peptide III (CTAP-III). Clin Res 37: 55AGoogle Scholar
  11. 11.
    Bamzai AK, Kretschmer RR (1978) Enhancement of antigen-induced leukocyte histamine release by a mononuclear cell-derived factor. J Allergy Clin Immunol 62: 137Google Scholar
  12. 12.
    Bascom R, Pipkorn U, Lichtenstein LM, Naclerio RM (1988) The influx of inflammatory cells into nasal washings during the late response to antigen challenge: effect of systemic steroid pretreatment. Am Rev Respir Dis 138: 406Google Scholar
  13. 13.
    Battey J, Max EE, McBride WO, Swan D, Leder P (1982) A processed human immunoglobulin E gene has moved to chromosome 9. Proc Natl Acad Sci USA 79: 5956Google Scholar
  14. 14.
    Behrens BL, Clark RAF, Marsh W, Larsen GL (1984) Modulation of the late asthmatic response by antigen-specific immunoglobulin G in an animal model. Am Rev Respir Dis 130: 1134Google Scholar
  15. 15.
    Blackley CH (1959) Experimental researches on the causes and nature of catarrhus aestivus (hayfever or hay asthma) 1873. Bailliere, Tindell and Cox, London, pp 77–81Google Scholar
  16. 16.
    Bochner BS, Charlesworth EN, Lichtenstein LM, Gillis S, Dinarello C, Schleimer RP (1990) Interleukin-1 (IL-1) is released during the cutaneous allergic late-phase response (LPR) to antigen (Ag). FASEB J (in press)Google Scholar
  17. 17.
    Charlesworth EN, Iliopoulos O, MacDonald SM, Kagey-Sobotka A, Lichtenstein LM (1989) Cells and secretagogues involved in the human late-phase response. Int Arch Allergy Appl Immunol 88: 50Google Scholar
  18. 18.
    Creticos PS, Peters SP, Adkinson NF, Naclerio RM, Hayes EC, Norman PS, Lichtenstein LM (1984) Peptide leukotriene release after antigen challenge in patients sensitive to ragweed. N Engl J Med 310: 1626Google Scholar
  19. 19.
    Dolovich J, Hargreave FE, Chalmers R, Shier KJ, Gauldie J, Bienenstock J (1973) Late cutaneous allergic responses in isolated IgE-dependent reactions. J Allergy Clin Immunol 52: 38Google Scholar
  20. 20.
    Durham SR, Lee TH, Cromwell O, Shaw RJ, Merrett TG, Merrett J, Cooper P, Kay AB (1984) Immunologic studies in allergen-induced late phase asthmatic reactions. J Allergy Clin Immunol 74: 49Google Scholar
  21. 21.
    Eidinger D, Wilkinson R, Rose B (1964) A study of the cellular response in the immune reaction utilizing the skin window technique. J Allergy 35: 77Google Scholar
  22. 22.
    Ezeamuzie IC, Assem ESK (1983) A study of histamine release from human basophils and lung mast cells by products of lymphocyte stimulation. Agents Actions 13: 222Google Scholar
  23. 23.
    Felarca AB, Lowell FC (1971) The accumulation of eosinophils and basophils at skin sites as related to intensity of skin reactivity and symptoms of atopic disease. J Allergy Clin Immunol 48: 125Google Scholar
  24. 24.
    Findlay SR, Dvorak AM, Kagey-Sobotka A, Lichtenstein LM (1981) Hyperosmolar triggering of histamine release from human basophils. J Clin Invest 67: 160Google Scholar
  25. 25.
    Fisher RH, Weiss M, Kagey-Sobotka A, Lichtenstein LM, Adkinson N (1988) Response to platelet-derived histamine-releasing factor (PD-HRF) is associated with allergic but not non-allergic asthma. Int Cong Allergology Clin Immunol (ICACI) 9: 249Google Scholar
  26. 26.
    Grant JA, Dupree E, Goldman AS, Schultz DR, Jackson AL (1975) Complement-mediated release of histamine from human leukocytes. J Immunol 144: 1101Google Scholar
  27. 27.
    Guo C-B, Liu MC, Galli SJ, Kagey-Sobotka A, Lichtenstein LM (1990) The histamine containing cells in the late-phase response in the lung are basophils. J Allergy Clin Immunol (in press)Google Scholar
  28. 28.
    Haak-Frendscho M, Aral N, Arai K-I, Baeza ML, Finn A, Kaplan AP (1988) Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release. J Clin Invest 82: 17Google Scholar
  29. 29.
    Ida S, Hook JJ, Siraganian RP, Notkins A (1980) Enhancement of IgE-mediated histamine release from human basophils by immunospecific lymphokines. Clin Exp Immunol 41: 380Google Scholar
  30. 30.
    Iliopoulos O, Proud D, Lichtenstein LM, Kagey-Sobotka A, Reticos PS, Adkinson NF, Mac-Donald SM, Norman PS, Naclerio RM (1987) Relationship between early (ER), late (LPR) and rechallenge (RCR) responses to nasal challenge. J Allergy Clin Immunol 79: 253Google Scholar
  31. 31.
    Ishizaka T, Ishizaka K (1974) Mechanisms of passive sensitization. IV. Dissociation of IgE molecules from basophil receptors at acid pH. J Immunol 112: 1078Google Scholar
  32. 32.
    Kagey-Sobotka A, Dembo M, Goldstein B, Lichtenstein LM (1979) Antigen-specific desensitization of human basophils. J Immunol 122: 511Google Scholar
  33. 33.
    Kaplan AP, Haak-Frendscho M, Fauci A, Dinarello C, Halbert E (1985) A histamine-releasing factor from activated human mononuclear cells. J Immunol 135: 2027Google Scholar
  34. 34.
    Kuna P, Alam R, Kuzminska B, Rozniecki J (1989) The effect of preseasonal immunotherapy on the production of histamine-releasing factor (HRF) by mononuclear cells from patients with seasonal assthma: results of a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol 83: 816Google Scholar
  35. 35.
    Lett-Brown MA, Thueson DO, Plank DE, Duffy L, Grant JA (1984) Histamine-releasing activity. V. Characterization and purification using high-performance liquid chromatography. Cell Immunol 87: 445Google Scholar
  36. 36.
    Lett-Brown MA, Thueson DO, Plank DE, Langford MP, Grant JA (1984) Histamine-releasing activity. IV. Molecular heterogeneity of the activity from stimulated human thoracic duct lymphocytes. Cell Immunol 87: 434Google Scholar
  37. 37.
    Liu MC, Proud D, Lichtenstein LM, MacGlashan DW, Schleimer RP, Adkinson NF, Kagey-Sobotka A, Schulman ES, Plaut M (1986) Human macrophage-derived histamine releasing activity is due to IgE-dependent factors. J Immunol 136: 2588Google Scholar
  38. 38.
    Lohman IC, Halonen M (1986) Purification of rabbit serum IgE. Fed Proc 45: 388Google Scholar
  39. 39.
    MacDonald SM, Lichtenstein LM, Proud D, Plaut M, Naclerio RM, MacGlashan DW, Kagey-Sobotka A (1987) Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 139: 506Google Scholar
  40. 40.
    MacDonald SM, Kagey-Sobotka A, Proud D, Naclerio RM, Lichtenstein LM (1987) Histaminereleasing factor release mechanism and responding population. J Allergy Clin Immunol 79: 248Google Scholar
  41. 41.
    MacDonald SM, Schleimer RP, Kagey-Sobotka A, Gillis S, Lichtenstein LM (1989) Recombinant IL-3 induces histamine release from human basophils. J Immunol 142: 3527Google Scholar
  42. 42.
    MacGlashan DW Jr, Mogowski M, Lichtenstein LM (1983) Studies of antigen binding on human basophils. II. Continued expression of antigen specific IgE during antigen-induced desensitization. J Immunol 130: 2337Google Scholar
  43. 43.
    Mackiewicz A, Ganapathi MK, Schultz D, Kushner I (1987) Monokines regulate glycosylation of acute-phase proteins. J Exp Med 166: 253Google Scholar
  44. 44.
    Massey WA, Randall TC, Kagey-Sobotka A, Warner JA, MacDonald SM, Gillis S, Allison AC, Lichtenstein LM (1989) Recombinant human interleukin 1α and 1β potentiate IgE-mediated histamine release from human basophils. J Immunol 143: 1875Google Scholar
  45. 45.
    McLean J, Garkowski A, Solomon W, Matthews K (1971) Changes in airway resistance on antigen challenge in allergic rhinitis. Clin Allergy 1: 63Google Scholar
  46. 46.
    Naclerio RM, Meier HL, Kagey-Sobotka A, Adkinson NF, Meyers DA, Norman PS, Lichtenstein LM (1983) Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis 128: 597Google Scholar
  47. 47.
    Naclerio RM, Togias A, Proud D, Kagey-Sobotka A, Adkinson NF, Plaut M, Norman PS, Lichtenstein LM (1985) Inflammatory mediators in late antigen-induced rhinitis. N Engl J Med 313: 65Google Scholar
  48. 48.
    Nagy L, Lee TH, Kay AB (1982) Neutrophil chemotactic activity in antigen-induced late asthmatic reactions. N Engl J Med 306: 497Google Scholar
  49. 49.
    Orchard MA, Kagey-Sobotka A, Proud D, Lichtenstein LM (1986) Basophil histamine release induced by a substance from stimulated platelets. J Immunol 136: 2240Google Scholar
  50. 50.
    Pene J, Rousset F, Briere F, Chretien I, Bonnefoy J-Y, Spits H, Yokota T, Arai N, Arai K-I, Banchereau J, De Vries JE (1988) IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons γ and α. and prostaglandin E2. Proc Natl Acad Sci USA 85: 6880Google Scholar
  51. 51.
    Pepys J, Turner-Warwick M, Dawson PL, Hinton KFW (1968) Arthus (type III) skin test reactions in man. Clinical and immunopathological features. Proceedings of the 6th Congress of the International Association of Allergology. Excerpta Med Int Congr Ser 162: 221Google Scholar
  52. 52.
    Peterson BA, Nilsson A, Stalenheim G (1975) Induction of histamine release and desensitization in human leukocytes. J Immunol 114: 1581Google Scholar
  53. 53.
    Plaut M, Liu MC, Conrad DH, Proud D, MacGlashan DW, Kagey-Sobotka A, Lichtenstein LM (1986) Histamine release from human basophils is induced by IgE-dependent factor(s) derived from human lung macrophages and an Fcε receptor-positive human B cell line. Trans Assoc Am Phys 98: 305Google Scholar
  54. 54.
    Pruzansky JJ, Grammer LC, Patterson R, Roberts M (1983) Dissociation of IgE from receptors on human basophils. I. Enhanced passive sensitization for histamine release. J Immunol 131: 1949Google Scholar
  55. 55.
    Sampson HA, Broadbent KR, Bernhisel-Broadbent J (1989) Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N Engl J Med 321: 228Google Scholar
  56. 56.
    Sarfati M, Luo H, Delespesse G (1989) IgE synthesis by chronic lymphocytic leukemia cells. J Exp Med 170: 1775Google Scholar
  57. 57.
    Schleimer RP, Gillespie E, Lichtenstein LM (1981) Release of histamine from human leukocytes stimulated with the tumor promoting phorbol esters. J Immunol 126: 570Google Scholar
  58. 58.
    Schulman ES, Proud D, Liu MC, MacGlashan DW, Lichtenstein LM, Plaut M (1985) Human lung macrophages induce histamine release from basophils and mast cells. Am Rev Respir Dis 131: 230Google Scholar
  59. 59.
    Sedgwick JD, Holt PG, Turner KI (1981) Production of a histamine-releasing lymphokine by antigen or mitogen stimulated human peripheral T cells. Clin Exp Immunol 45: 399Google Scholar
  60. 60.
    Shampain MP, Behrens BL, Larsen GL, Henson PM (1982) Animal model of late pulmonary responses to Alternaria challenge. Am Rev Respir Dis 126: 493Google Scholar
  61. 61.
    Siraganian RP, Hook WA (1977) Mechanism of histamine release by formyl methionyl containing peptides. J Immunol 119: 2078Google Scholar
  62. 62.
    Solley GO, Gleich GJ, Jordan RE, Schroeter AL (1976) Late phase of the immediate wheal and flare skin reaction: its dependence on IgE antibodies. J Clin Invest 54: 408Google Scholar
  63. 63.
    Strickland DB, Turner KJ, Holt BJ, Niemensma NP (1988) Histamine-releasing factor-Cellular source and kinetics of production are influenced by characteristics of antigen. Allergy Proc 9: 317Google Scholar
  64. 64.
    Subramanian N, Bray MA (1987) Interleukin 1 causes histamine release from human basophils and mast cells in vitro. J Immunol 138: 271Google Scholar
  65. 65.
    Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine-releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells. J Immunol 123: 626Google Scholar
  66. 66.
    Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine-releasing activity (HRA). II. Interaction with basophils and physicochemical characterization. J Immunol 123: 633Google Scholar
  67. 67.
    Thueson DO, Plank PE, Langford MP, Lett-Brown MA, Grant JA (1982) Basophilic histamine release: lymphocyte-derived histamine-releasing activity. Fed Proc 4: 964Google Scholar
  68. 68.
    Valent P, Besemer J, Muhm M, Majdic O, Lechner K, Bettelheim P (1989) Interleukin 3 activates human blood basophils via high-affinity binding sites. Proc Natl Acad Sci USA 86: 5542Google Scholar
  69. 69.
    Warner JA, Pienkowski MM, Plaut M, Norman PS, Lichtenstein LM (1986) Identification of histamine-releasing factor(s) in the late phase of cutaneous IgE-mediated reactions. J Immunol 136: 2583Google Scholar
  70. 70.
    Weiss M, Fisher RH, Kagey-Sobotka A, Proud D, Lichtenstein LM, Adkinson NF (1988) In vivo response to platelet-derived histamine-releasing factor. J Allergy Clin Immunol 81: 224Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Susan M. MacDonald
    • 1
  • Lawrence M. Lichtenstein
    • 1
  1. 1.Division of Allergy and Clinical Immunology, Department of MedicineThe Johns Hopkins University School of Medicine at The Johns Hopkins Asthma and Allergy CenterBaltimoreUSA

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