Molecular and Cellular Biochemistry

, Volume 53, Issue 1, pp 129–152

Tyrosine hydroxylase regulation in the central nervous system

  • Joseph M. Masserano
  • Norman Weiner

DOI: 10.1007/BF00225250

Cite this article as:
Masserano, J.M. & Weiner, N. Mol Cell Biochem (1983) 53: 129. doi:10.1007/BF00225250


Tyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Increased or decreased neuronal activity, stress, lesions, drug effects, endocrinological manipulations and experimental models of hypertension are associated with alterations in tyrosine hydroxylase activity in the central nervous system. In many of these instances, the changes in the activity of tyrosine hydroxylase in the central nervous system that occur are localized to discrete catecholaminergic pathways and nuclei in the brain. The purpose of this review is to summarize and assess this information and to provide insight into the function of catecholamine systems in the brain and their interactions with other putative neurotransmitter systems.

Copyright information

© Martinus Nijhoff Publishers 1983

Authors and Affiliations

  • Joseph M. Masserano
    • 1
  • Norman Weiner
    • 1
  1. 1.Department of PharmacologyUniversity of Colorado Health Sciences Center, School of MedicineDenverUSA

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