Human Genetics

, Volume 95, Issue 3, pp 265–269 | Cite as

Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization

  • Jefferson Y. Chan
  • Mei-Chi Cheung
  • Paolo Moi
  • Kaiman Chan
  • Yuet Wai Kan
Original Investigation


A family of human genes encoding basic-leucine zipper (bZIP) transcription factors, p45-NF-E2, Nrf1 and Nrf2, have been isolated independently. Whereas the encoded proteins of the three genes share highly conserved regions distinct from other bZIP families such as Jun or Fos, remaining regions diverged considerably from each other. Chromosomal localization by fluorescence insitu hybridization demonstrates that these genes are nonsyntenic. p45-NF-E2 mapped to chromosome 12q13.1–13.3, whereas Nrf1 and 2 mapped to 17q21.3 and 2q31, respectively. However, these three genes were probably derived from a single ancestor by chromosomal duplication as other genes that also map in these regions are related to one another.


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Jefferson Y. Chan
    • 1
  • Mei-Chi Cheung
    • 2
  • Paolo Moi
    • 3
  • Kaiman Chan
    • 2
  • Yuet Wai Kan
    • 1
    • 2
  1. 1.Department of Laboratory MedicineUniversity of CaliforniaSan FranciscoUSA
  2. 2.Howard Hughes Medical Institute at the University of CaliforniaSan FranciscoUSA
  3. 3.Istituto di Clinica e Biologia dell' Eta EvolutivaUniversita di CagliariItaly

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