Advertisement

Human Genetics

, Volume 95, Issue 1, pp 99–101 | Cite as

The human interleukin-10 receptor gene maps to chromosome 11q23.3

  • Tadayoshi Taniyama
  • Setsuo Takai
  • Emi Miyazaki
  • Ryutaro Fukumura
  • Junko Sato
  • Yoshiro Kobayashi
  • Tadashi Hirakawa
  • Kevin W. Moore
  • Kiyomi Yamada
Short Communication

Abstract

The human interleukin-10 receptor (IL-10R) gene has previously been mapped to chromosome 11. Here, we have determined the precise location of the human IL-10R gene by the fluorescence in situ hybridization method, and have found that the IL-10R gene maps to chromosome 11q23.3.

Keywords

Internal Medicine Metabolic Disease Receptor Gene Chromosome 11q23 Hybridization Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cherif D, Dersarkissian H, Derre J, Tokino T, Nakamura Y, Berger R (1992) The 11q23 breakpoint in acute leukemia with t(11–19)(q23-p13) is distal to those of t(4–11), t(6–11) and t(9–11). Gene Chromosome Cancer 4:107–112Google Scholar
  2. Das S, Cotter FE, Gibbons B, Dhut S, Young BD (1991) CD3G is within 200 kb of the leukemic t(4;11) translocation breakpoint. Gene Chromosome Cancer 3:44–47Google Scholar
  3. De Waal-Malefyt R, Abrams J, Bennett B, Figdor C, Vries JE de (1991a) IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174:1209–1220CrossRefPubMedGoogle Scholar
  4. De Waal-Malefyt R, Haanen J, Spits H, Roncarolo MG, Te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, Vries JE de (1991b) IL-10 and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II MHC expression. J Exp Med 174:915–924PubMedGoogle Scholar
  5. Fiorentino DF, Bond MW, Mosmann TR (1989) Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170:2081–2095Google Scholar
  6. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A (1991) IL-10 inhibits cytokine production by activated macrophages. J Immunol 147:3815–3822Google Scholar
  7. Go NF, Castel BE, Barrett R, Kastelein R, Dang W, Mosmann TR, Moore KW, Howard M (1990) Interleukin 10 (IL-10) at, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 172:1625–1631Google Scholar
  8. Gold DP, Dongen JJ van, Morton CC, Rruns GA, Van den Elsen P, Geurts van Kessel AH, Terhorst C (1987) The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci USA 84:1664–1668Google Scholar
  9. Kobayashi H, Espinosa R, Thirman MJ, Gill HJ, Fernald AA, Diaz MO, Lebeau MM, Rowley JD (1993) Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization. Blood 82:547–551Google Scholar
  10. Liu Y, Wei SHY, Ho ASY. Waal-Malefyt R de, Moore KW (1994) Expression cloning and characterization of a human IL-10 receptor. J Immunol 152:1821–1829PubMedGoogle Scholar
  11. MacNeil IA, Suda T, Moore KW, Mosmann TR, Zlotnik A (1990) 1L-10, a novel growth cofactor for mature and immature T cells. J Immunol 145:4167–4173Google Scholar
  12. Meerabux JM, Cotter FE, Kearney L, Nizetic D, Dhut S, Gibbons B, Lister TA, Young BD (1994) Molecular cloning of a novel 11q23 breakpoint associated with non-Hodgikin's lymphoma. Oncogene 9:893–898Google Scholar
  13. Moore KW, O'Garra A. Wall-Malefyt R de, Vieira P, Mosmann TR (1993) Interleukin-10. Annu Rev Immunol 11:165–190Google Scholar
  14. Noguchi M, Yi H, Rosenblatt HM, Filipovitch AH, Adelstein S, Modi WS, McBride OW, Leonard WJ (1993) Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73:147–157Google Scholar
  15. Radice P, Tunnacliffe A (1992) Distinct breakpoints in band-11q23 of the t(4–11) and t(11–14) associated with leukocyte malignancy. Gene Chromosome Cancer 5:50–56Google Scholar
  16. Rousset F, Garcia E, DeFrance T, Peronne C, Hsu DH, Kastelein R, Moore KW, Banchereau J (1992) IL-10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 89:1890–1893Google Scholar
  17. Takai S, Yamada K, Hirayama N, Miyajima A, Taniyama T (1994) Mapping of the human gene encoding the mutual signal-transducing subunit (β-chain) of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin 5 (IL-5) receptor complexes to chromosome 22q13. 1. Hum Genet 93:198–200Google Scholar
  18. Takahashi E, Hori T, O'Connell P, Leppert M, O'Connell P, Leppert M, White R (1990) R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (Co12A1). Hum Genet86:14–16Google Scholar
  19. Te Velde AA, de Waal-Malefyt R, Huijbens RJF, de Vries JE, Figdor CG (1992) IL-10 stimulates monocyte FcγR surface expression and cytotoxic activity. Distinct regulation of antibodydependent cellular cytotoxicity by IFN-γ, IL-4, and IL-10. J Immunol 149:4048–4052Google Scholar
  20. Van den Elsen P, Bruns G, Gerhard DS, Pravtcheva D, Jones C, Housman D, Ruddle FA, Orkin S, Terhorst C (1985) Assignment of the gene encoding for the T3-delta subunit of the T3-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci USA 82:2920–2924Google Scholar
  21. Viegas-Pequignot E, Dutrillaux B (1978) Une methode simple pour obtenir des prophases et des prometaphases. Ann Genet (Paris) 21:122–125Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Tadayoshi Taniyama
    • 1
  • Setsuo Takai
    • 2
  • Emi Miyazaki
    • 1
    • 3
  • Ryutaro Fukumura
    • 1
    • 3
  • Junko Sato
    • 1
    • 3
  • Yoshiro Kobayashi
    • 3
  • Tadashi Hirakawa
    • 4
  • Kevin W. Moore
    • 5
  • Kiyomi Yamada
    • 2
  1. 1.Laboratory of Immunoregulation, Department of ImmunologyNational Institute of HealthTokyoJapan
  2. 2.Department of Genetics, Research InstituteInternational Medical Center of JapanTokyoJapan
  3. 3.Laboratory of Molecular Immunology, Faculty of ScienceToho UniversityChibaJapan
  4. 4.Central Research LaboratoriesAjinomoto Co. Ltd.KanagawaJapan
  5. 5.Department of ImmunologyDNAX Research Institute of Molecular and Cellular BiologyPalo AltoUSA

Personalised recommendations