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Molecular and Cellular Biochemistry

, Volume 42, Issue 2, pp 65–82 | Cite as

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

  • Jacques Kruh
Article

Summary

Sodium butyrate, at millimolar concentrations, when added to cell cultures produces many morphological and biochemical modifications in a reversible manner. Some of them occur in all cell lines. They concern regulatory mechanisms of gene expression and cell growth: an hyperacetylation of histone resulting from an inhibition of histone deacetylase and an arrest of cell proliferation are almost constantly observed. Some other modifications vary from one cell type to another: induction of proteins, including enzymes, hormones, hemoglobin, inhibition of cell differentiation, reversion of transformed characteristics of cells to normal morphological and biochemical pattern, increase in interferon antiviral efficiency and induction of integrated viruses. Most if not all these effects of butyrate could result from histone hyperacetylation, from changes in chromatin structures as measured by accessibility to DNases and from modifications in cytoskeleton assembly. We do not know at the present time whether butyrate acts on a very specific target site in cell or if it acts on several cell components.

Keywords

Cell Growth Interferon Cell Differentiation Regulatory Mechanism Butyrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1982

Authors and Affiliations

  • Jacques Kruh
    • 1
  1. 1.Institut de Pathologie et Biologie Cellulaire et Moléculaire Université Paris V CNRS LA 85 INSERM U 137Paris

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