, Volume 37, Issue 6, pp 461–465 | Cite as

The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes

  • Kimmo I. Virtaneva
  • Pavla Angelisová
  • Thomas Baumruker
  • Václav Hořejší
  • Heli Nevanlinna
  • Jim Schröder
Original Articles


CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a sub-population of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.


Gene Family Somatic Cell Surface Antigen Related Protein Human Chromosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Kimmo I. Virtaneva
    • 1
  • Pavla Angelisová
    • 2
  • Thomas Baumruker
    • 3
  • Václav Hořejší
    • 2
  • Heli Nevanlinna
    • 4
  • Jim Schröder
    • 1
  1. 1.Department of GeneticsUniversity of HelsinkiHelsinkiFinland
  2. 2.Institute of Molecular GeneticsCzechoslovak Academy of SciencesPraha 4Czechoslovakia
  3. 3.Department of ImmunopharmacologySandoz Research Institute Ltd.ViennaAustria
  4. 4.Department of Obstetrics and GynecologyUniversity of HelsinkiHelsinkiFinland

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