Cell and Tissue Research

, Volume 209, Issue 1, pp 161–166 | Cite as

Thyrotropes in the pituitary are target cells for 1,25 dihydroxy vitamin D3

  • Madhabananda Sar
  • Walter E. Stumpf
  • Hector F. DeLuca


In the anterior pituitary of the rat, target cells of 1,25 (OH)2 vitamin D3 are identified as those that secrete thyroid stimulating hormone by means of a combined technique of thaw-mount autoradiography and immunohistochemistry. The results for the first time provide evidence that suggests a central effect of 1,25 (OH)2 vitamin D3 on the modulation of thyrotropin secretion in a manner similar to that of other steroid hormones at the level of the pituitary.

Key words

1,25 (OH)2 vitamin D3 Thyrotropes Autoradiography Immunohistochemistry 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Madhabananda Sar
    • 1
  • Walter E. Stumpf
    • 1
  • Hector F. DeLuca
    • 1
    • 2
  1. 1.Departments of Anatomy and PharmacologyUniversity of North CarolinaChapel HillUSA
  2. 2.Department of BiochemistryUniversity of WisconsinMadisonUSA

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