Human Genetics

, Volume 89, Issue 5, pp 487–490

Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

  • J. T. Elder
  • A. Åström
  • U. Pettersson
  • J. J. Voorhees
  • J. M. Trent
Original Investigations

DOI: 10.1007/BF00219171

Cite this article as:
Elder, J.T., Åström, A., Pettersson, U. et al. Hum Genet (1992) 89: 487. doi:10.1007/BF00219171

Summary

Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. T. Elder
    • 1
  • A. Åström
    • 1
  • U. Pettersson
    • 1
  • J. J. Voorhees
    • 1
  • J. M. Trent
    • 2
  1. 1.Department of DermatologyThe University of Michigan Medical SchoolAnn ArborUSA
  2. 2.Department of Radiation Oncology and Human GeneticsThe University of Michigan Medical SchoolAnn ArborUSA

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