Cell and Tissue Research

, Volume 255, Issue 3, pp 553–557 | Cite as

Prostaglandins may play a signal-coupling role during phagocytosis in Amoeba proteus

  • Robert D. Prusch
  • Stella-Maris Goette
  • Paula Haberman


Phagocytosis in Amoeba proteus can be induced with prostaglandins (PG). In addition, arachidonic acid (the fatty acid precursor to the PG-2 series) also induces phagocytosis. The induction of phagocytosis with arachidonic acid can be partially inhibited by the cyclooxygenase inhibitor indomethacin. Phagocytosis in the amoeba can also be induced with the chemotactic peptide N-formylmethionyl-leucylphenylalanine (NFMLP). The peptide presumably induces phagocytosis by interacting with receptors on the amoeba surface, which may initiate the release of arachidonic acid from membrane lipids. NFMLP-induced phagocytosis can also be partially inhibited by indomethacin. It is suggested that PG's or biochemically related substances may play a signal-coupling role during phagocytosis in the amoeba.

Key words

Phagocytosis Prostaglandins Amoeba proteus (Protozoa) 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Robert D. Prusch
    • 1
  • Stella-Maris Goette
    • 2
  • Paula Haberman
    • 3
  1. 1.Department of Life SciencesGonzaga UniversitySpokaneUSA
  2. 2.Department of Biological SciencesStanford UniversityStanfordUSA
  3. 3.University of Washington, School of MedicineSeattleUSA

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