Human Genetics

, Volume 90, Issue 5, pp 542–544

The human interleukin-6 receptor α chain gene is localized on chromosome 1 band q21

  • Petra M. C. Kluck
  • Joop Wiegant
  • Rumo P. M. Jansen
  • Marian W. J. Bolk
  • Anton K. Raap
  • Roel Willemze
  • James E. Landegent
Original Investigations

Abstract

The human interleukin-6 receptor α chain (IL6Rα) gene was regionally mapped to chromosome 1 bridization probes, partially overlapping lambda clones encompassing 28 kb of the genomic region of the gene were used. These clones were isolated using a polymerase chain reaction (PCR)-generated fragment of the 3′ noncoding region of the gene. This localization confirms and extends the provisional assignment of the IL6Rα gene to chromosome 1, for which a panel of somatic cell hybrids was used.

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Petra M. C. Kluck
    • 1
  • Joop Wiegant
    • 2
  • Rumo P. M. Jansen
    • 1
  • Marian W. J. Bolk
    • 1
  • Anton K. Raap
    • 2
  • Roel Willemze
    • 1
  • James E. Landegent
    • 1
  1. 1.Department of HematologyUniversity Medical CenterRC LeidenThe Netherlands
  2. 2.Department of Cytochemistry and CytometrySylvius Laboratories, University of LeidenAL LeidenThe Netherlands
  3. 3.Department of HematologyBldg 1; C2-R, University Medical CenterRC LeidenThe Netherlands

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