Cell and Tissue Research

, Volume 230, Issue 3, pp 671–776

Preliminary observations of satellite cells in undamaged fibres of the rat soleus muscle assaulted by a snake-venom toxin

  • Catherine Klein-Ogus
  • John B. Harris
Article

Summary

Satellite cells were studied in the undamaged part of the rat soleus muscle rendered partially necrotic by a subcutaneous injection of notexin, the myotoxic toxin purified from the venom of the Australian snake Notechis scutatus scutatus. Nuclei of satellite cells were twice as numerous as in the controls, with a decreasing gradient in the number of satellite cells with distance from the necrotic area. The cells were in an activated state with an increased cytoplasmic volume and prominent organelles. Occasionally, mitosis of some satellite cells was observed. Between the satellite cell and the muscle fibre, an unusually wide space was frequently seen, within which a “new” basal lamina was often visible. It is suggested that the role of the satellite cells of undamaged muscle fibres in the regeneration of necrotic muscle is worthy of more detailed investigation.

Key words

Satellite cells Skeletal muscle Snake-venom toxin Muscle regeneration Electron microscopy Rat 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Catherine Klein-Ogus
    • 1
  • John B. Harris
    • 1
  1. 1.Muscular Dystrophy Group Research Laboratories, Newcastle General HospitalNewcastle upon TyneEngland
  2. 2.Muscular Dystrophy Group Research Laboratories, Newcastle General HospitalNewcastle upon TyneEngland

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