Theoretical and Applied Genetics

, Volume 85, Issue 8, pp 953–960 | Cite as

Bayesian analysis of linkage between genetic markers and quantitative trait loci. I. Prior knowledge

  • I. Hoeschele
  • P. M. VanRaden
RFLP Report
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Accepted:

Summary

Prior information on gene effects at individual quantitative trait loci (QTL) and on recombination rates between marker loci and QTL is derived. The prior distribution of QTL gene effects is assumed to be exponential with major effects less likely than minor ones. The prior probability of linkage between a marker and another single locus is a function of the number and length of chromosomes, and of the map function relating recombination rate to genetic distance among loci. The prior probability of linkage between a marker locus and a quantitative trait depends additionally on the number of detectable QTL, which may be determined from total additive genetic variance and minimum detectable QTL effect. The use of this prior information should improve linkage tests and estimates of QTL effects.

Key words

Genetic markers Quantitative trait loci Linkage analysis Bayesian method Prior information 
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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • I. Hoeschele
    • 1
  • P. M. VanRaden
    • 2
  1. 1.Department of Dairy ScienceVirginia Polytechnic Institute and State UniversityBlacksburgUSA
  2. 2.Agricultural Research Service, U.S. Department of AgricultureAnimal Improvement Programs LaboratoryBeltsvilleUSA

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