Human Genetics

, Volume 93, Issue 3, pp 349–350 | Cite as

A new highly polymorphic DNA restriction site marker in the 5′ region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhabdomyosarcoma

  • Corinne Besnard-Guérin
  • Webster K. Cavenee
  • Irene Newsham
DNA Variants
Received:
Revised:

Abstract

We have isolated a new marker (cos11-5TH) that detects an MspI restriction fragment length polymorphism in the 5′ region of the human tyrosine hydroxylase gene (TH) on chromosome band 11p15.5. This region of human chromosome 11 contains several important loci for disease phenotypes including Beckwith-Wiedemann syndrome (BWS), Wilms' tumor, and embryonal rhabdomyosarcoma. Thus, identification of new polymorphic markers in this region are important for future gene mapping and linkage analyses. To better define the region of 11p15.5 deleted in embryonal rhabdomyosarcoma, this new marker was used to investigate allelic losses in embryonal rhabdomyosarcoma tumors.

Keywords

Restriction Fragment Length Polymorphism Tyrosine Hydroxylase Polymorphic Marker Rhabdomyosarcoma Disease Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Corinne Besnard-Guérin
    • 1
  • Webster K. Cavenee
    • 1
    • 2
    • 3
  • Irene Newsham
    • 1
    • 2
  1. 1.Ludwig Institute for Cancer Research, University of California-San Diego, School of MedicineLa JollaUSA
  2. 2.Department of MedicineUniversity of California-San Diego, School of MedicineLa JollaUSA
  3. 3.Center for Molecular Genetics, University of California-San Diego, School of MedicineLa JollaUSA

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