The clinical investigator

, Volume 71, Issue 1, pp 42–45 | Cite as

A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea

  • A. Plettenberg
  • A. Stoehr
  • H. -J. Stellbrink
  • H. Albrecht
  • W. Meigel
Original Articles


In a prospective, open, uncontrolled study 25 patients infected with the human immunodeficiency virus with chronic refractory diarrhea and either confirmed cryptosporidiosis (n=7) or absence of demonstrable pathogenic organisms (n =18) were treated with a daily oral dose of 10 g of an immunoglobulin preparation from bovine colostrum over a period of 10 days. Among the 7 patients with cryptosporidiosis, this treatment led to complete remission in 3 and partial remission in 2. Among the 18 patients with diarrhea and negative stool culture, complete remission of diarrhea was obtained in 7 and partial remission in 4. In the remaining 2 patients with cryptosporidiosis and the 7 patients with diarrhea but no demonstrable pathogens treatment produced no significant improvement of the diarrhea. Subsequent doubling of the Lactobin dose (2 × 10 g daily) in 8 of the nonresponders led to complete remission in one case and at least partial remission in a further 4 patients. Treatment of refractory diarrhea with 10 g immunoglobulins from bovine colostrum per day constitutes an important therapeutic approach and led to complete (40%) or partial (24%) remission of diarrhea in 64% of the patients described here.

Key words

AIDS Diarrhea Bovine colostrum Cryptosporidiosis 



human immunodeficiency virus


acquired immunodeficiency syndrome


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  1. 1.
    Davidson GP, Daniels E, Nunan H, Moore AG, Whuyte PBD, Franklin K, McCloud PI, Moore DJ (1989) Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet 2:709–714Google Scholar
  2. 2.
    Dieterich DT, Chachoua A, Lafleur F, Worell CV (1988) ganciclovir treatment of gastrointestinal infections caused by cytomegalovirus in patients with AIDS. Rev Infect Dis [Suppl 10]3:532–538Google Scholar
  3. 3.
    Dolan SA, Boesman-Finkelstein M, Finkelstein RA (1989) Inhibition of enteropathogenic bacteria by human milk whey in vitro. Pediatr Infect Dis J 8:430–436Google Scholar
  4. 4.
    Ebina T, Sato A, Umezu K, Ishida N, Ohyma S, Oizumi A, Aikawa K, Katagiri S, Katsushima N, Imai A, Kitaoka S, Suzuki H, Konno K (1985) Prevention of rotavirus infection by oral administration of cow colostrum containing antihuman rotavirus antibody. Med Microbiol Immunol 174:177–185Google Scholar
  5. 5.
    Gazzard BG (1990) Practical advice for the gastroenterologist dealing with symptomatic HIV disease. Gut 31:733–755Google Scholar
  6. 6.
    Heise W, Mostertz P, Arasteh K, Skörde J, L'age M (1988) Gastrointestinale Befunde bei der HIV-Infection. Dtsch Med Wochenschr 113:1588–1593Google Scholar
  7. 7.
    Hilpert H, Gerber H, Peyer ED, Nussle D (1974) Gastrointestinal passage of bovine anti-E. coli milk immunglobulins in infants. Nestle Res News 7:143–138Google Scholar
  8. 8.
    Kim KS, Dunn K, McGeary SA, Stiehm ER (1984) Efficacy of orally administered immune serum globulin against type III group B streptococcal colonization and systemic disease in an infant rat model. Pediatr Res 18:1329–1331Google Scholar
  9. 9.
    Lewis-Jones DI, Reynolds GJ (1983) A suggested role for precolostrum in preterm and sick newborn infants. Acta Paediatr Scand 72:13–17Google Scholar
  10. 10.
    Mach JP, Pahud JJ (1971) Secretory IgA, a major immunoglobulin in most bovine external secretions. J Immunol 106:552–563Google Scholar
  11. 11.
    McClead RE, Gregory SA (1984) Resistance of bovine colostral anti-cholera toxin antibody to in vitro and in vivo proteolysis. Infect Immun 44:474–478Google Scholar
  12. 12.
    Mietens C, Keinhorst H (1979) Treatment of infantile E. coli gastroenteritis with specific bovine anti-E. coli milk immunoglobulins. Eur J Pediatr 132:239–252Google Scholar
  13. 13.
    Nord J, Ma P, Dijohn D, Tzipori S, Tacket CO (1990) Treatment with bovine hyperimmune colostrum of cryptosporidal diarrhea in AIDS patients. AIDS 6:581–584Google Scholar
  14. 14.
    Pape JW (1988) Treatment of gastrointestinal infections. AIDS 2:161–167Google Scholar
  15. 15.
    Porter P (1972) Immunglobulins in bovine mammary secretions — quantitative changes in early lactation and absorption. Neonatal Calf Immunol 23:225–237Google Scholar
  16. 16.
    Sachs MK, Dickinson GM (1989) Intestinal infections in patients with AIDS. Postgrad Med 85:309–314Google Scholar
  17. 17.
    Schrager LK (1988) Bacterial infections in AIDS patients. AIDS 2:183–189Google Scholar
  18. 18.
    Seto A, Okabe T, Sosaki N, Ito Y (1976) Opsonic activity and O-agglutinins against Escherichia coli in bovine colostrum. Am J Res 37:635–638Google Scholar
  19. 19.
    Stephan WQ, Dichtelmüller H, Lissner R (1990) Antibodies from colostrum in oral immunotherapy. J Clin Chem Clin Biochem 28:19–23Google Scholar
  20. 20.
    Tzipori S, Robertson D, Chapmann C (1986) Remission of diarrhoea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum. BMJ 293:1276–1277Google Scholar
  21. 21.
    Ungar BLP, Ward DJ, Fayer R, Quinn CA (1990) Cessation of Cryptosporidium-associated diarrhoea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterol 98:486–489Google Scholar
  22. 22.
    Zinkernagel RM, Colombini A (1975) Passive oral immunization with bovine immunoglobulins: enteroparhogenetic Escherichia coli from infants and bovine anti-E. coli lactoserum assayed in the rabbit ileal loop model. Med Microbiol Immunol 162:1–7Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • A. Plettenberg
    • 1
  • A. Stoehr
    • 1
  • H. -J. Stellbrink
    • 2
  • H. Albrecht
    • 2
  • W. Meigel
    • 1
  1. 1.Allgemeines Krankenhaus St. GeorgHIV-AmbulanzHamburg 1FRG
  2. 2.Universitätsklinik EppendorfMedizinische PoliklinikHamburg

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