The clinical investigator

, Volume 71, Issue 1, pp 42–45 | Cite as

A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea

  • A. Plettenberg
  • A. Stoehr
  • H. -J. Stellbrink
  • H. Albrecht
  • W. Meigel
Original Articles

Summary

In a prospective, open, uncontrolled study 25 patients infected with the human immunodeficiency virus with chronic refractory diarrhea and either confirmed cryptosporidiosis (n=7) or absence of demonstrable pathogenic organisms (n =18) were treated with a daily oral dose of 10 g of an immunoglobulin preparation from bovine colostrum over a period of 10 days. Among the 7 patients with cryptosporidiosis, this treatment led to complete remission in 3 and partial remission in 2. Among the 18 patients with diarrhea and negative stool culture, complete remission of diarrhea was obtained in 7 and partial remission in 4. In the remaining 2 patients with cryptosporidiosis and the 7 patients with diarrhea but no demonstrable pathogens treatment produced no significant improvement of the diarrhea. Subsequent doubling of the Lactobin dose (2 × 10 g daily) in 8 of the nonresponders led to complete remission in one case and at least partial remission in a further 4 patients. Treatment of refractory diarrhea with 10 g immunoglobulins from bovine colostrum per day constitutes an important therapeutic approach and led to complete (40%) or partial (24%) remission of diarrhea in 64% of the patients described here.

Key words

AIDS Diarrhea Bovine colostrum Cryptosporidiosis 

Abbreviations

HIV

human immunodeficiency virus

AIDS

acquired immunodeficiency syndrome

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • A. Plettenberg
    • 1
  • A. Stoehr
    • 1
  • H. -J. Stellbrink
    • 2
  • H. Albrecht
    • 2
  • W. Meigel
    • 1
  1. 1.Allgemeines Krankenhaus St. GeorgHIV-AmbulanzHamburg 1FRG
  2. 2.Universitätsklinik EppendorfMedizinische PoliklinikHamburg

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