Journal of Molecular Medicine

, Volume 74, Issue 7, pp 347–352

Transcription, adipocyte differentiation, and obesity

  • J. Auwerx
  • G. Martin
  • M. Guerre-Millo
  • B. Staels
Review

Abstract

Differentiation of adipogenic precursor cells into mature adipocytes is a complex phenomenon, characterized by an ordered expression of adipocyte-specific genes, triggered by a set of interacting transcription factors. The most important transcription factors involved in this process are the γ form of peroxisome proliferator activated receptors (PPARγ) and the various members of the CCAAT enhancer binding proteins (α, β, and δ). In addition to PPARγ and these enhancer binding proteins, several other transcription factors, including ADD-1 (SRE-BP), HMGI-C, are involved in regulating this process. Altered activity and/or expression of these transcription factors, will induce the expression of target genes in the differentiating cells, ultimately resulting in the phenotypical characteristics of the adipocytes. It is speculated that modulation of these transcription factors by either pharmacological or dietary manipulations might influence adipocyte differentiation and prove beneficial in the prevention and treatment of obesity.

Key words

Adipocytes CCAATT enhancer binding protein Gene expression Nuclear receptors Peroxisome proliferator activated receptors 

Abbreviations

ADD-1

Adipocyte differentiation and determination factor-1

bHLH

Basic helix-loop-helix transcription factors

C/EBP

CCAATT enhancer binding protein

HMG

High-mobility group

PPAR

Peroxisome proliferator activated receptor

PRE

Preadipocyte repressor element

WAT

White adipose tissue

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. Auwerx
    • 1
  • G. Martin
    • 1
  • M. Guerre-Millo
    • 2
  • B. Staels
    • 1
  1. 1.INSERM U 325, Département d'AthéroscléroseInstitut PasteurLilleFrance
  2. 2.INSERM U177, Institut des CordeliersParisFrance

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