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Human Genetics

, Volume 93, Issue 2, pp 211–212 | Cite as

Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes γ-aminobutyraldehyde

  • John D. McPherson
  • John J. Wasmuth
  • Gloria Kurys
  • Regina Pietruszko
Short Communications

Abstract

A cDNA clone of the E3 isozyme of human liver aldehyde dehydrogenase consisting of a 1320-base pair (bp) coding region and a 180-bp non-coding region at the 3′ end was used for chromosomal localization of the E3 gene. Using a panel of human/hamster somatic cell hybrids we have localized, the gene coding for the E3 isozyme to human chromosome 1.

Keywords

Internal Medicine Aldehyde Metabolic Disease Somatic Cell Code Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Altherr MR, Smith B, MacDonald ME, Hall L, Wasmuth JJ (1989) Isolation of a novel mildly repetitive DNA sequence that is predominantly located at the terminus of the short arm of chromosome 4 near the Huntington's disease gene. Genomics 5:581–588Google Scholar
  2. Ambroziak W, Pietruszko R (1991) Human aldehyde dehydrogenase: activity with aldehyde metabolites of monoamines, diamines and polyamines. J Biol Chem 266:13011–13018Google Scholar
  3. Braun T, Grzesik KH, Bober E, Singh S, Agarwal DP, Goedde HW (1986) The structural gene for the mitochondrial aldehyde dehydrogenase maps to human chromosome 12. Hum Genet 73:365–367Google Scholar
  4. Hsu LC, Yoshida A, Mohandas T (1986) Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2. Am J Hum Genet 38:641–648Google Scholar
  5. Kurys G, Ambroziak W, Pietruszko R (1989) Human aldehyde dehydrogenase: purification and characterization of a third isozyme with low Km for γ-aminobutyraldehyde. J Biol Chem 264:4715–4721Google Scholar
  6. Kurys G, Shah P, Kikonyogo A, Reed D, Ambroziak W, Pietruszko R (1993) Human aldehyde dehydrogenase: cDNA cloning and primary structure of the isozyme that catalyses dehydrogenation of γ-aminobutyraldehyde. Eur J Biochem 218:273–281Google Scholar
  7. Liptay S, Schmid RM, Perkins ND, Meltzer P, Altherr MR, McPherson JD, Wasmuth JJ, Nabel GJ (1992) Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2. Genomics 13:287–292Google Scholar
  8. Santisteban I, Powey S, West LF, Parrington JM, Hopkinson DA (1985) Chromosome assignment, biochemical and immunological studies on the human aldehyde dehydrogenase, ALDH3. Ann Hum Genet 49:87–100Google Scholar
  9. Smith M, Hiroshige S, Duester G, Saxon P, Carlock L, Wasmuth J (1985) Confirmation of the assignment of the gene coding for mitochondrial aldehyde dehydrogenase (ALDH2) to human chromosome 12. Cytogenet Cell Genet 40:748Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • John D. McPherson
    • 1
  • John J. Wasmuth
    • 1
  • Gloria Kurys
    • 2
  • Regina Pietruszko
    • 2
  1. 1.Department of Biological ChemistryUniversity of CaliforniaIrvineUSA
  2. 2.Center of Alcohol Studies and Department of Molecular Biology and BiochemistryRutgers UniversityPiscatawayUSA

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