International Orthopaedics

, Volume 15, Issue 1, pp 35–37 | Cite as

Prostaglandins in osteoid osteoma

  • F. Greco
  • F. Tamburrelli
  • G. Ciabattoni
Article

Summary

Osteoid osteoma is a tumour of bone characterised by pain which is relieved by aspirin and nonsteroidal anti-inflammatory drugs. Very high levels of prostaglandins have been found in the lesion. In five patients with osteoid osteoma, prostaglandin E2 (PGE2) and prostacyclin (PGI2) synthesis in the nidus yielded 1155.6±496.5 (mean±SD) and 245.2±89.8 pg/mg respectively, values which are 33 and 26 times higher than in fragments of normal bone. The sclerotic bone around the nidus produced both prostaglandins at the same rate as normal bone. In three patients the excretion rate of the major urinary metabolite of systemic PGI1 was reduced to 50% one month after removal of the tumour. The urinary excretion rate of 6-keto-PGF1α, reflecting intrarenal PGI2 synthesis, was not changed after operation. These results offer new insight into the pain mechanism in osteoid osteoma.

Résumé

L'ostéome ostéoïde est une tumeur osseuse caractérisée par des douleurs qui sont calmées par l'aspirine et les anti-inflammatoires non stéroïdiens. Des taux très élevés de prostaglandines ont été trouvés dans cette lésion. Chez trois malades présentant un ostéome ostéoïde la prostaglandine E2 (PGE2) et la prostacycline (PGI2) synthétisés dans le nidus atteignaient respectivement 1155.6±496.5 et 245.2±89.8 pg/mg, valeurs qui étaient 33 et 26 fois plus élevées que dans des fragments d'os normal. L'os scléreux entourant le nidus produisait les deux prostaglandines au même taux que l'os normal. Chez trois malades le taux d'excrétion des principaux métabolites urinaires de la PGI2 systémique était réduit de moitié un mois après l'ablation de la tumeur. Le taux d'excrétion urinaire de la 6-keto-PGF1α, traduisant la synthèse rénale de la PGI2, n'a pas été modifié par l'opération. Ces résultats permettent une nouvelle approche du mécanisme de la douleur dans l'ostéome ostéoöide.

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • F. Greco
    • 1
  • F. Tamburrelli
    • 1
  • G. Ciabattoni
    • 2
  1. 1.Department of Orthopaedic SurgeryCatholic University of Rome, Policlinico Universitario ARomeItaly
  2. 2.Department of PharmacologyCatholic University, School of MedicineRomeItaly

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