Human Genetics

, Volume 96, Issue 6, pp 726–730 | Cite as

Inheritance of migraine investigated by complex segregation analysis

  • Michael Bjørn Russell
  • Lennart Iselius
  • Jes Olesen
Original Investigation


Migraine is the most common neurological disorder, affecting about 20% of adults. The mode of inheritance was analyzed in the two main types of migraine, migraine without aura (MO) and migraine with aura (MA), by complex segregation analysis using the computer program POINTER. We included 126 probands with MO and 127 probands with MA from the general population. Firstdegree relatives and spouses were blindly interviewed by a neurological research fellow. The complex segregation analysis indicated that both MO and MA have multifactorial inheritance without generational difference.


Internal Medicine General Population Migraine Computer Program Metabolic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Michael Bjørn Russell
    • 1
    • 2
  • Lennart Iselius
    • 3
  • Jes Olesen
    • 1
  1. 1.Department of NeurologyGlostrup Hospital, University of CopenhagenGlostrupDenmark
  2. 2.The Glostrup Population Studies, Department of Internal Medicine CGlostrup Hospital, University of CopenhagenGlostrupDenmark
  3. 3.Department of SurgeryKarolinska HospitalStockholmSweden

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