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Human Genetics

, Volume 96, Issue 6, pp 671–673 | Cite as

Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5

  • Nessan Bermingham
  • Renate Hillermann
  • Fraser Gilmour
  • Joanne E. Martin
  • Elizabeth M. C. Fisher
Original Investigation

Abstract

Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. We have mapped the gene encoding GDNF by two independent methods: using a cell hybrid panel and by fluorescent in situ hybridisation. We find GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3

Keywords

Internal Medicine Cell Surface Metabolic Disease Glial Cell Neuronal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Nessan Bermingham
    • 1
  • Renate Hillermann
    • 1
  • Fraser Gilmour
    • 1
    • 2
  • Joanne E. Martin
    • 2
  • Elizabeth M. C. Fisher
    • 1
  1. 1.Department of Biochemistry and Molecular GeneticsSt. Mary's Hospital Medical School, Imperial CollegeLondonUK
  2. 2.Department of HistopathologyThe London Hospital Medical CollegeWhitechapel, LondonUK

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