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The clinical investigator

, Volume 70, Issue 6, pp 529–534 | Cite as

Acquired protein S deficiency

  • B. Kemkes-Matthes
Molecular Medicine Review

Summary

Hereditary deficiencies of coagulation inhibitors like antithrombin 111, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach — in part — the extent realised by hereditary protein S deficiency. Thus, acquired protein S deficiencies seem to be one source of thromboembolic complications occurring in nephrotic syndrome, acute phase reactions, malignancy and pregnancy. In this presentation disease states accompanied by acquired protein S deficiency and the mechanisms leading to these alterations are discussed.

Key words

Acquired protein S deficiency Thrombosis 

Abbreviations

AT III

antithrombin III

C4b-BP

C4b-binding protein

DIC

disseminated intravascular coagulation

SLE

systemic lupus erythematosus

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • B. Kemkes-Matthes
    • 1
  1. 1.Zentrum für Innere Medizin der Justus Liebig Universität GießenGießen

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