Human Genetics

, Volume 95, Issue 6, pp 716–716 | Cite as

Frequent sequence variant in the human tyrosine hydroxylase gene

  • Barbara Lüdecke
  • Klaus Bartholomé
DNA Variants


A polymorphism of human tyrosine hydroxylase changing the amino acid 81Val to 81Met is located in exon 2 of the human tyrosine hydroxylase gene.


Internal Medicine Tyrosine Metabolic Disease Sequence Variant Tyrosine Hydroxylase 
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  1. Byerley W, Plaetke R, Hoff M, Jensen S, Holik J, Lubbers A, Reimherr F, Mellon C (1992) Tyrosine hydroxylase gene not linked to manic-depression in seven of eight pedigrees. Hum Hered 42:259–263Google Scholar
  2. Grima B, Lamouroux A, Boni C, Julien J-F, Javoy-Agid F. Mallet J (1987) A single gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. Nature 326:707–711Google Scholar
  3. Segawa M, Ohmi K, Itoh S (1971) Childhood basal ganglia disease with remarkable response to l-Dopa, “hereditary basal ganglia disease with marked diurnal fluctations”. Therapie 24: 667–672Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Barbara Lüdecke
    • 1
  • Klaus Bartholomé
    • 1
  1. 1.University Children's HospitalBochumGermany

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