Human Genetics

, Volume 95, Issue 6, pp 641–644 | Cite as

Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34–35, a region frequently affected in haematological neoplasms

  • Sharad Kumar
  • Deborah L. White
  • Setsuo Takai
  • Suzanne Turczynowicz
  • Christopher A. Juttner
  • Timothy P. Hughes
Original Investigation


Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1β-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.


Caenorhabditis Elegans Chromosome Segment Mouse Gene Suppressor Function Tumour Suppressor Function 
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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Sharad Kumar
    • 1
  • Deborah L. White
    • 1
  • Setsuo Takai
    • 2
  • Suzanne Turczynowicz
    • 1
  • Christopher A. Juttner
    • 1
  • Timothy P. Hughes
    • 1
  1. 1.Hanson Centre for Cancer Research, Institute of Medical and Veterinary ScienceAdelaideAustralia
  2. 2.Department of Genetics, Research InstituteInternational Medical Center of JapanTokyoJapan

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