Advertisement

Human Genetics

, Volume 87, Issue 5, pp 618–620 | Cite as

Chromosomal localization of the human D3 dopamine receptor gene

  • Maryvonne Le Coniat
  • Pierre Sokoloff
  • Josette Hillion
  • Marie-Pascale Martres
  • Bruno Giros
  • Catherine Pilon
  • Jean-Charles Schwartz
  • Roland Berger
Short Communications

Summary

A novel dopamine D3 receptor gene that may be involved in psychiatric diseases has recently been characterized. It has been assigned to chromosome 3 by hybridization with a D3 receptor probe to human sorted chromosomes, and localized to band 3q 13.3 by in situ hybridization.

Keywords

Internal Medicine Dopamine Metabolic Disease Receptor Gene Dopamine Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Caubet JF, Mathieu-Mahul D, Bernheim A, Larsen CJ, Berger R (1985) Human proto-oncogene c-mos maps to 8q 11. EMBO J 4:2245–2248Google Scholar
  2. Feinberg AP, Vogelstein B (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6–13PubMedGoogle Scholar
  3. Gelernter J, Moises H, Grandy D (1989) Exclusion of schizophrenia trait from regions of D2 dopamine receptor and porphobilinogen deaminase genes (abstract). In: 28th Annual Meeting of the American College of Neuropsychopharmacology, Maui, Hawai, p 216Google Scholar
  4. Giros B, Martres MP, Sokoloff P, Schwartz JC (1990) cDNA cloning of the human dopaminergic receptor and chromosome identification. CR Acad Sci [III] 311:501–508Google Scholar
  5. Grandy DK, Marchionni MA, Makam H, Stofko RE, Alfano M, Frothingham L, Fischer JB, Burke-Howie KJ, Bunzow JR, Server AC, Civelli O (1989a) Cloning of the cDNA and gene for a human D2 dopamine receptor. Proc Natl Acad Sci USA 84:9762–9766Google Scholar
  6. Grandy DK, Litt M, Allen L, Bunzow JR, Marchionni M, Makan H, Reed L, Magenis RE, Civelli O (1989b) The human dopamine D2 receptor gene is located on chromosome 11 at q22–q23 and identifies a TaqI RFLP. Am J Hum Genet 45:778–785Google Scholar
  7. Harper ME, Saunders GF (1981) Localization of single copy DNA sequences on G banded human chromosomes by in situ hybridization. Chromosoma 83:431–439Google Scholar
  8. Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96Google Scholar
  9. Kennedy JL, Giuffra LA, Moises HW, Cavalli-Sforza LL, Pakstis A, Kidd JR, Castiglione CL, Sjogren B, Wetterberg L, Kidd K (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 on a northern Swedish pedigree. Nature 336:167–170Google Scholar
  10. McGue M, Gottesman II, Rao DC (1983) Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Am J Hum Genet 33:1161–1178Google Scholar
  11. Rousseau-Merck MF, Bernheim A, Chardin P, Miglierina R, Tavitian A, Berger R (1988) The ras-related gene maps to chromosome 7p 15–22. Hum Genet 79:132–136Google Scholar
  12. Rousseau-Merck MF, Zahraoui A, Bernheim A, Miglierina R, Tavitian A, Berger R (1989) Chromosome mapping of the human ras-related rab 3A gene to 19p13. 2. Genomics 5:694–698Google Scholar
  13. Sherrington R, Brynjolfsson J, Petursson H, Potter M, Dudleston K, Barraclough B, Wasmuth J, Dodds M, Gurling H (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336:164–167Google Scholar
  14. Sillar R, Young B (1981) A new method for the preparation of metaphase chromosomes for flow analysis. Histochem Cytochem 29:74–78Google Scholar
  15. Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347:146–151Google Scholar
  16. Sparkes RS, Klisak I, Kaufman D, Mohandas T, Tobin AJ, McGinnis JF (1986) Assignment of the rhodopsin gene to human chromosome three, region 3q21–3q24 by in situ hybridization studies. Curr Eye Res 5:797–798Google Scholar
  17. Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang Y, Israel Y, Seeman P, O'Dowd BF (1990) Human dopamine D1 recepor encoded by an intronless gene on chromosome 5. Nature 347:80–83Google Scholar
  18. Yunis JJ, Sawyer JR, Ball DW (1978) Characterization of banding patterns of metaphase —prophase G —banded chromosomes and their use in gene mapping. Cytogenet Cell Genet 22:679–683Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Maryvonne Le Coniat
    • 1
  • Pierre Sokoloff
    • 2
  • Josette Hillion
    • 1
  • Marie-Pascale Martres
    • 2
  • Bruno Giros
    • 2
  • Catherine Pilon
    • 2
  • Jean-Charles Schwartz
    • 2
  • Roland Berger
    • 1
  1. 1.Unité de Génétique Cellulaire et Moléculaire des Leucémies (U.301) de l'INSERMInstitut de Génétique MoléculaireParisFrance
  2. 2.Unité de Neurobiologie et Pharmacologie (U.109) de l'INSERMCentre Paul BrocaParisFrance

Personalised recommendations