Human Genetics

, Volume 84, Issue 2, pp 185–187 | Cite as

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily

  • William S. Modi
  • Michael Dean
  • Hector N. Seuanez
  • Naofumi Mukaida
  • Kouji Matsushima
  • Stephen J. O'Brien
Original Investigations

Summary

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • William S. Modi
    • 1
  • Michael Dean
    • 1
  • Hector N. Seuanez
    • 2
  • Naofumi Mukaida
    • 3
  • Kouji Matsushima
    • 2
  • Stephen J. O'Brien
    • 2
  1. 1.Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research FacilityFrederickUSA
  2. 2.Laboratory of Viral CarcinogenesisNational Cancer InstituteFrederickUSA
  3. 3.Laboratory of Molecular ImmunoregulationNational Cancer InstituteFrederickUSA

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