Human Genetics

, Volume 84, Issue 2, pp 185–187

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily

  • William S. Modi
  • Michael Dean
  • Hector N. Seuanez
  • Naofumi Mukaida
  • Kouji Matsushima
  • Stephen J. O'Brien
Original Investigations

Summary

Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor) of the platelet factor 4 gene superfamily reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • William S. Modi
    • 1
  • Michael Dean
    • 1
  • Hector N. Seuanez
    • 2
  • Naofumi Mukaida
    • 3
  • Kouji Matsushima
    • 2
  • Stephen J. O'Brien
    • 2
  1. 1.Biological Carcinogenesis and Development Program, Program Resources, Inc., National Cancer Institute, Frederick Cancer Research FacilityFrederickUSA
  2. 2.Laboratory of Viral CarcinogenesisNational Cancer InstituteFrederickUSA
  3. 3.Laboratory of Molecular ImmunoregulationNational Cancer InstituteFrederickUSA

Personalised recommendations