Roux's archives of developmental biology

, Volume 204, Issue 4, pp 259–270 | Cite as

Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects

  • Artur Kania
  • Hugo J. Bellen
Original Articles

Abstract

The Drosophila neuromusculin (nrm) gene encodes an immunoglobulin-like (Ig-like) cell adhesion molecule expressed in the precursors of the embryonic peripheral nervous system (PNS), in the midline precursors of the central nervous system (CNS), and in muscles. During the initial phases of CNS axonogenesis, nrm is expressed in cells involved in the development of commissures and longitudinal tracts. Mutations which alter expression of nrm mRNAs cause aberrant development of commissures and longitudinal axon pathways. Defects in the PNS and muscles of nrm mutants are also observed. In most nrm embryos, abnormal development can be detected in a subset of abdominal segments; however, in approximately 1 of 10 nrm embryos, the defects extend to all segments. Herein, we present evidence that nrm plays an important role in early morphogenesis, possibly by mediating or facilitating inductive cell contacts and movements.

Key words

Ig-like domains Cell adhesion Peripheral and central nervous system Muscles Drosophila 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Artur Kania
  • Hugo J. Bellen

There are no affiliations available

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