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The clinical investigator

, Volume 71, Issue 7, pp 537–541 | Cite as

Zinc supplementation stimulates tetanus antibody formation and soluble interleukin-2 receptor levels in chronic hemodialysis patients

  • W. Holtkamp
  • H. -P. Brodersen
  • T. Stollberg
  • J. Thiery
  • C. Falkner
Original Article

Summary

Immunodepression in end-stage renal disease has been associated with zinc deficiency. In a controlled study serum zinc levels, serum concentrations of soluble interleukin-2 receptor (sIL-2R), and tetanus IgG antibody titers were measured in 65 hemodialysis patients before and after intravenous zinc supplementation for 2 months. The hemodialysis patients had significantly lower predialysis serum zinc concentrations compared to healthy controls (63 ± 1.65 versus 126 ± 4.6 μg/dl, P < 0.001). Serum zinc concentrations increased to the normal range in the zinc-treated patients. After zinc substitution tetanus antibody titers rose significantly (0.81 ± 0.12 versus 1.22 ± 0.12U/ml, P < 0.01). Pretreatment sIL-2R levels were elevated in 95% of examined patients. A further increase in sIL-2R was observed after zinc supplementation (234 ± 14 versus 285 ± 21 U/ml, P<0.05). The results suggest that zinc induces the activation of T lymphocytes and T-cell dependent B lymphocytes in chronic uremic patients in vivo.

Key words

Zinc Hemodialysis Immunity Soluble interleukin-2 receptor Tetanus antibodies 

Abbreviations

IL-2

interleukin-2

sIL-2R

soluble interleukin-2 receptor

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • W. Holtkamp
    • 1
  • H. -P. Brodersen
    • 1
  • T. Stollberg
    • 2
  • J. Thiery
    • 3
  • C. Falkner
    • 3
  1. 1.Medizinische KlinikKrankenhaus Maria Hilf GmbH MönchengladbachRWTH AachenGermany
  2. 2.Institut für LaboratoriumsmedizinMönchengladbachGermany
  3. 3.Institut für Klinische Chemie, Klinikum GroBhadernUniversität MünchenGermany

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