Archives of gynecology

, Volume 234, Issue 2, pp 87–93 | Cite as

Ultrasound study of ovarian morphology in women with polycystic ovary syndrome before and during treatment with an oestrogen/progestogen preparation

  • S. Venturoli
  • R. Paradisi
  • E. Saviotti
  • S. Barnabé
  • E. Porcu
  • R. Fabbri
  • C. Flamigni
Original Papers


Women with polycystic ovarian disease were treated with oral estrogens and progestogens and their ovarian volume, ovarian texture and uterine size were studied by ultrasound before and during treatment. A significant decrease in the volume and in the number of follicles in the ovaries was seen.

Hormone therapy thus temporarily restores normal ovarian morphology in subjects with polycystic ovaries. The uterus did not change significantly during treatment.

Key words

Ultrasonography Polycystic ovarian disease Estroprogestin treatment 


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  1. 1.
    Berger MJ, Taymor ML, Patton WC (1975) Gonadotropin levels and secretory patterns in patients with typical and atypical polycystic ovarian disease. Fertil Steril 26:619–626Google Scholar
  2. 2.
    Campbell S, Goessens L, Goswamy R, Whitehead M (1982) Real-time ultrasonography for determination of ovarian morphology and volume. A possible early screening test for ovarian cancer? Lancet I:425–426Google Scholar
  3. 3.
    Erickson GF (1982) Follicular maturation and atresia. In: Flamigni C, Givens JR (eds) The gonadotropins: basic science and clinical aspects in females. Academic Press, London New York, p 177Google Scholar
  4. 4.
    Flamigni C, Venturoli S, Lodi S, Bolelli GF, Nardi M, Di Leo A (1977) Role of androgens in clinical disorders. In: Martini L, Motta M (eds) Androgens and antiandrogens. Raven Press, New York, p 201Google Scholar
  5. 5.
    Flamigni C, Venturoli S, Filicori M, Bulletti C, Paradisi R (1980) L'ovaio policistico: considerazioni eziopatogenetiche, istopatologiche, biochimiche, diagnostiche e terapeutiche. J Endocrinol Invest (Suppl 2) 3:181–189Google Scholar
  6. 6.
    Frölich M, Vader HL, Walma ST, De Rooy HAM (1980) the influence of long-term treatment with cyproterone acetate or a cyproterone acetate-ethinyl oestradiol combination on androgen levels in blood of hirsute women. J Steroid Biochem 12:499–501Google Scholar
  7. 7.
    Givens JR, Andersen RN, Wiser WL, Fish SA (1974) Dynamics of suppression and recovery of plasma FSH, LH, androstenedione and testosterone in polycystic ovarian disease using an oral contraceptive. J Clin Endocrinol Metab 38:727–735Google Scholar
  8. 8.
    Gohari P, Berkowitz RL, Hobbins JC (1977) Prediction of intrauterine growth retardation by determination of total intrauterine volume. Am J Obstet Gynecol 127:255–260Google Scholar
  9. 9.
    Kratochwil A, Urban G, Friedrich F (1972) Ultrasonic tomography of the ovaries. Ann Chir Gynaecol 61:211–214Google Scholar
  10. 10.
    McNatty KP, Moore-Smith D, Makris A, Osathanoodh R, Ryan KJ (1979) The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of oocyte in vivo and in vitro. J Clin Endocrinol Metab 49:851–860Google Scholar
  11. 11.
    Palmer R, De Brux J (1967) Resultates histologiques, biochimiques et therapeutiques obtenus chez les femmes dont les ovaries avaient ete diagnostiques Stein-Leventhal a la coelioscopie. Bull Fed Soc Gynec Obstet franc 19:405–412Google Scholar
  12. 12.
    Parisi L, Tramonti M, Casciano S, Zurli A, Gazzarini O (1982) The role of ultrasound in the study of polycystic ovarian disease. J Clin Ultrasound 10:167–172Google Scholar
  13. 13.
    Rajaniemi HJ, Rönnberg L, Kauppila A, Ylöstalo P, Vihko R (1980) Luteinizing hormone receptors in ovarian follicles of patients with polycystic ovarian disease. J Clin Endocrinol Metab 51:1054–1057Google Scholar
  14. 14.
    Stein IF, Leventhal ML (1935) Amenorrhoea associated with bilateral ovarian disease. Am J Obstet Gynecol 29:181–191Google Scholar
  15. 15.
    Swanson M, Sauerbrei EE, Cooperberg PL (1981) Medical implications of ultrasonically detected polycystic ovaries. J Clin Ultrasound 9:219–222Google Scholar
  16. 16.
    Weigen JF, Stevens GM (1967) Pelvic pneumography in the diagnosis of polycystic disease of the ovary, including Stein-Leventhal syndrome. A comparison with normal pelvic pneumogram. Am J Roentgenol 100:680–687Google Scholar
  17. 17.
    Zemlyn S (1974) Comparison of pelvic ultrasonography and pneumography for ovarian size. J Clin Ultrasound 2:331–339Google Scholar

Copyright information

© J. F. Bergmann Verlag 1983

Authors and Affiliations

  • S. Venturoli
    • 1
  • R. Paradisi
    • 1
  • E. Saviotti
    • 1
  • S. Barnabé
    • 2
  • E. Porcu
    • 1
  • R. Fabbri
    • 1
  • C. Flamigni
    • 1
  1. 1.Institute of Reproductive Physiology and PathologyUniversity of BolognaBolognaItaly
  2. 2.Iind Institute of Obstetrics and GynecologyUniversity of BolognaBolognaItaly

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