Human Genetics

, Volume 85, Issue 3, pp 376–378 | Cite as

Mapping the human gene coding for chromosomal protein HMG-17

  • Nicholas Popescu
  • David Landsman
  • Michael Bustin
Short Communications


The functional gene coding for nonhistone chromosomal protein HMG-17, a nucleosomal binding protein that may confer unique properties to the chromatin structure of active genes, has been mapped to band 1p36.1. The multiple, nonfunctional, HMG-17 retropseudogenes are scattered over several chromosomes.


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  1. Dracopoli NC, Stanger BZ, Lager M, Housman DE (1988) Localization of the FGR protoncogene on the genetic linkage map of human chromosome 1p. Genomics 3:124–128Google Scholar
  2. Einck L, Bustin M (1985) The intracellular distribution and function of the high mobility group chromosomal proteins. Exp Cell Res 156:295–310Google Scholar
  3. Landsman D, Soares N, Gonzalez FJ, Bustin M (1986) Chromosomal protein HMG-17: complete cDNA sequence and evidence for a multigene family. J Biol Chem 261:7479–7484Google Scholar
  4. Landsman D, McBride OW, Bustin M (1989) Human nonhistone chromosomal protein HMG-17: identification, characterization, chromosome localization of RFLPs of a functional gene from the large multigene family. Nucleic Acids Res 17:2301–2314Google Scholar
  5. Mitchell AL, Bale AE, Bustin M, Landsman D, Popescu N, McBride OW (1989) Localization of HMG-17 gene to chromosome band 1p35–36. 1 (abstract). (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:1045Google Scholar
  6. Pash J, Popescu N, Matocha M, Rapaport S, Bustin M (1990) Proc Natl Acad Sci USA 87:3836–3840Google Scholar
  7. Petersen MB, Economou EP, Slaugenhaupt SA, Chakravarty A, Antonarakis SE (1990) Linkage analysis of human HMG-14 gene on chromosome 21 using a GT dinucleotide repeat as polymeric marker. Genomics 7:136–138Google Scholar
  8. Popescu NC, Amsbaugh SC, DiPaolo JA, Tronick SR, Aaronson SA, Swan DC (1985a) Chromosomal localization of three human ras genes in in situ molecular hybridization. Somat Cell Mol Genet 11:149–155Google Scholar
  9. Popescu NC, Amsbaugh SC, Swan DC, DiPaolo JA (1985b) Induction of chromosome banding by trypsin/EDTA for gene mapping by in situ hybridization. Cytogenet Cell Genet 39:73–74Google Scholar
  10. Srikantha T, Landsman D, Bustin M (1987) Retropseudogenes for chromosomal protein HMG-17. J Mol Biol 197:401–413Google Scholar
  11. Tronick SR, Popescu NC, Cheah MSC, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo TA, Robbins KC (1985) Isolation and hromosomal localization of the human fgr protooncogene, a distinct member of tryosine kinase gene family. Proc Natl Acad Sci USA 82:6595–6599Google Scholar
  12. Weintraub H, Groudine M (1976) Chromosomal subunits in active genes have an altered conformation. Science 193:848–850Google Scholar
  13. Weisbrod S (1982) Active chromatin. Nature 297:289–295Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Nicholas Popescu
    • 1
  • David Landsman
    • 2
  • Michael Bustin
    • 3
  1. 1.Laboratory of Biology, National Cancer InstituteBethesdaUSA
  2. 2.National Center for Biotechnology Information, NLMBethesdaUSA
  3. 3.Laboratory of Molecular Carcinogenesis, Building 37, Room 3D12, National Cancer Institute, National Institutes of HealthBethesdaUSA

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