Cancer Immunology, Immunotherapy

, Volume 27, Issue 1, pp 77–81

Association between clinical symptoms and lymphocyte abnormalities in a population with chronic domestic exposure to industrial solvent-contaminated domestic water supply and a high incidence of leukaemia

  • V. S. Byers
  • A. S. Levin
  • D. M. Ozonoff
  • R. W. Baldwin
Original Article

Summary

An unusually high incidence of leukaemia and recurrent infections was noted in children exposed in utero to domestic water supply contaminated with industrial solvents including trichloroethylene, perchloroethylene and 1,2-transdichloroethylene. Medical and laboratory investigations were carried out on 28 family members of the patients with leukaemia with particular emphasis on the immunological system to determine if they displayed symptoms associated with acute or chronic exposure to these chlorinated hydrocarbons. The principal organ systems affected were neurological, immunological and cardiological. Damage to these systems was found in all subjects by history, physical and laboratory parameters. Damage to the immunological system was manifest by altered ratios of T lymphocyte subpopulations, increased incidence of auto-antibodies, increased infections and recurrent rashes.

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References

  1. 1.
    Blattner WA, Naiman L, Mann DL, Wimer RS, Dean JH, Fraumeni JF Jr (1978) Immunogenetic determinants of familial acute lymphocytic leukemia. Ann Intern Med 89:173–175Google Scholar
  2. 2.
    Feldman RG, Mayer RM, Taub A (1970) Evidence of peripheral neurotoxic effect of trichloroethylene. Neurology 20:599–606Google Scholar
  3. 3.
    Feldman RG, White RF, Travers PH (1988) Adverse health effects of pollutant exposure: Neurobehavioral disorders. In: Tarcher OR (ed) Principals and practice of environmental medicine. Plenum Press (in press)Google Scholar
  4. 4.
    Fukuda K, Takemoto K, Tsuruta H (1983) Inhalation carcinogenicity of trichloroethylene in mice and rats. Ind Health 21:243–254Google Scholar
  5. 5.
    Health Assessment document for trichloroethylene, final report (EPA/600/8-82/006F) (1985) Environmental Protection Agency, Wash D. C., 8–133Google Scholar
  6. 6.
    Herren-Freund SL, Pereira MA, Olsen G, De Angelo AB (1986) The carcinogenicity of trichlorethylene (TCE) and its metabolites, trichloroacetic acid (TCA) and dichloroacetic acid (DCA) in mouse liver. Proc Am Assoc Cancer Res 27:91Google Scholar
  7. 7.
    Hoffman RA, Kung PC, Hansen WP et al. (1981) Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood. Proc Natl Acad Sci USA 77:4914–4917Google Scholar
  8. 8.
    International Agency for Cancer Research (1982) Evaluation of the carcinogenic risk of chemicals to humans. IARC Monograph Suppl 4 247–249Google Scholar
  9. 9.
    Kimbrough RD, Mitchell FL, Houk VN (1985) Trichloroethylene: an update. J Toxicol Environ Health 15:369–383Google Scholar
  10. 10.
    Kotelchuck M, Parker G (1979) Woburn health data analysis, 1969–1978, Massachusetts Department of HealthGoogle Scholar
  11. 11.
    Lagakos SW, Wessen BJ, Zelen M (1986) An analysis of contaminated well water and health effects in Woburn, Massachusetts, J Am Stat Assoc 81:583–614Google Scholar
  12. 12.
    Lifson JD, Finch SL, Sasaki DT, Engleman EG (1985) Variables affecting T lymphocyte subsets in a volunteer blood donor population. Clin Immunol Immunopathol 36:151–160Google Scholar
  13. 13.
    Parker GS, Rosen SL (1981) Woburn: Cancer incidence and environmental hazards 1969–1978. Massachusetts Department of Health, Public Health Service-CDC-Atlanta EPI-80-37-2 (9/16/81)Google Scholar
  14. 14.
    Reinhardt CF, Mullin LS, Maxfield ME (1973) Epinephrine-induced cardiac arrhythmia potential of some common industrial solvents. J Occupat Med 15:953–955Google Scholar
  15. 15.
    Rose NR, Friedman H (eds) (1976) Manual of clinical immunology. Am Soc for Microbiol, Wash D.C.Google Scholar
  16. 16.
    Sanders VM, Tucker AN, White KL, Kauffmann BM, Hallett B, Carchman RA, Borzelleca JF, Munson AP (1982) Humoral and cell-mediated immune status in mice exposed to the trichloroethylene in the drinking water. Toxicol Appl Pharmacol 62:358–368Google Scholar
  17. 17.
    Thierstein ST, Hanigan JJ, Faul MD, Stuck PL (1960) Trichloroethylene anethesia in obstetrics. Obstet Gynecol 15:560–565Google Scholar
  18. 18.
    Waldorf PH, Cleary R (1983) Water distribution system, Woburn Massachusetts 1964–1979 Engineering Draft Report, Massachusetts Department of Environmental QualityGoogle Scholar
  19. 19.
    Waters EM, Gerstner HB, Huff JE (1977) Trichloroethylene I: An overview. J Toxicol Environ Health 2:671–707Google Scholar
  20. 20.
    Weintrub WS, Barr-Alderfer VA, Seelaus PA, Bodenheimer MM, Madeira SW Jr, Katz RI, Feldman MS, Agarwall JB, Banka VS, Helfant RH (1985) A sequential approach to the diagnosis of coronary artery disease using multivariate analysis. Am Heart J 109:99–1005Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • V. S. Byers
    • 1
    • 2
  • A. S. Levin
    • 2
  • D. M. Ozonoff
    • 3
  • R. W. Baldwin
    • 1
  1. 1.Cancer Research Campaign LaboratoriesUniversity of NottinghamNottinghamU. K.
  2. 2.Department of DermatologyUniversity of CaliforniaSan FranciscoUSA
  3. 3.School of Puplic HealthBoston UniversityBostonUSA

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