Cancer Immunology, Immunotherapy

, Volume 27, Issue 1, pp 69–76 | Cite as

Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells

  • Paola Allavena
  • Patrizia Lo Presti
  • Maria Di Bello
  • Valeria Lucchini
  • Andrea Lissoni
  • Gerardo Zanetta
  • Costantino Mangioni
  • Alberto Mantovani
Original Article
Received:
Accepted:

Summary

Peripheral blood lymphocytes (PBL) from 43 patients with histologically confirmed ovarian carcinoma were stimulated in mixed lymphocyte-tumor culture (MLTC) with purified autologous tumor cells. Positive results, assessed as lymphocyte proliferation, were observed in 21 cases (48.8%). Lymphoid cells associated with ascitic fluid or infiltrating solid masses were in general less reactive than PBL as only 3/11 cases had positive MLTC. Tumor cells isolated from peritoneal effusions showed no significant difference in stimulatory potential as compared to the primary tumor. These results suggest that in an appreciable proportion of ovarian carcinoma patients (approximately 50%), lymphocytes have the potential to react to autologous tumor cells. Comprehension of the immunological mechanisms of antitumor resistance may have direct practical relevance for more effective treatment of neoplasms.

Keywords

Cancer Patient Ovarian Cancer Primary Tumor Ovarian Carcinoma Peripheral Blood Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Paola Allavena
    • 1
  • Patrizia Lo Presti
    • 1
  • Maria Di Bello
    • 1
  • Valeria Lucchini
    • 2
  • Andrea Lissoni
    • 3
  • Gerardo Zanetta
    • 3
  • Costantino Mangioni
    • 3
  • Alberto Mantovani
    • 1
  1. 1.Laboratory of Human ImmunologyIstituto di Ricerche Farmacologiche “Mario Negri”MilanItaly
  2. 2.Department of HistopathologyS. Gerardo HospitalMonza, MilanItaly
  3. 3.Department of GynecologyS. Gerardo HospitalMonza, MilanItaly

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