Cancer Immunology, Immunotherapy

, Volume 16, Issue 3, pp 182–185 | Cite as

Defective interleukin-1 production by monocytes from patients with malignant disease

Interferon increases IL-1 production
  • Jean Herman
  • Michael C. Kew
  • Arthur R. Rabson
Original Articles


Interleukin-1 (IL-1) production by monocytes of patients with various forms of malignant disease was measured after activating the cells with either lipopolysaccharide or malignant K562 cells. Monocytes from all the patients with large tumour masses, including 10 patients with hepatocellular carcinoma, produced considerably less IL-1 than controls or patients with small tumour burdens. After treating control or patient monocytes with human leucocyte interferon for 1 h prior to activation, IL-1 production was markedly improved. Depressed IL-1 production is, therefore, a further aberration in mononuclear function observed in patients with cancer.


Carcinoma Cancer Research Interferon Hepatocellular Carcinoma Large Tumour 
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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Jean Herman
    • 1
    • 2
  • Michael C. Kew
    • 1
    • 2
  • Arthur R. Rabson
    • 1
    • 2
  1. 1.South African Medical Research Council Human Cellular Immunology UnitSchool of Pathology of the University of the WitwatersrandJohannesburgSouth Africa
  2. 2.S.A.I.M.R.JohannesburgSouth Africa

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