Human Genetics

, Volume 86, Issue 1, pp 73–75 | Cite as

The human corticosteroid binding globulin gene is located on chromosome 14q31–q32.1 near two other serine protease inhibitor genes

  • Gilles-Eric Seralini
  • Dominique Bérubé
  • Richard Gagné
  • Geoffrey L. Hammond
Original Investigations

Summary

Human corticosteroid binding globulin (CBG) cDNA fragments were radiolabeled and hybridized in situ to metaphase chromosome preparations. The results localized the CBG gene to the q31–q32.1 region of human chromosome 14. This location also contains the genes for two closely related serine protease inhibitors: alpha1-proteinase inhibitor and alpha1-antichymotrypsin. It is therefore likely that these genes evolved by duplication events, and it would appear that this region contains a series of functionally related genes.

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References

  1. Berman M, Minowada J, Loew JM, Ramsey MM, Ebie N, Knospe WH (1985) Burkitt cell acute lymphoblastic leukemia with partial expression of T-cell markers and subclonal chromosome abnormalities in a man with acquired immunodeficiency syndrome. Cancer Genet Cytogenet 16:341–347Google Scholar
  2. Bérubé D, Luu The V, Lachance Y, Gagné R, Labrie F (1990) Assignment of the human 3β-hydroxysteroid dehydrogenase gene to the p13 band of chromosome 1. Cytogenet Cell Genet 52:199–200Google Scholar
  3. Bissbort S, Hitzeroth HW, Wentzel DP du, Van den Berg CW, Senff H, Wienker TF, Bender K (1988) Linkage between the variegate porphyria (VP) and the alpha1-antitrypsin (PI) genes on human chromosome 14. Hum Genet 79:289–290Google Scholar
  4. De Moor P, Louwagie A (1980) Association of aberrant transcortin levels with HLA antigens of the B and C loci: high transcortin levels are frequently found in patients with lymphatic leukemia, hairy cell leukemia, or non-Hodgkin lymphoma. J Clin Endocrinol Metab 51:868–872Google Scholar
  5. Gyger M, Laverdiere M, Gagnon A, Perreault C, Cousineau S, Forest L (1985) 14q+ Abnormality with probable t(8∶14)(q24∶q32) in a young Haitian immigrant with acquired immunodeficiency syndrome and concomitant Burkitt's-like lymphoma. Cancer Genet Cytogenet 17:283–288Google Scholar
  6. Hammond GL (1990) Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins. Endocrinol Rev 11:65–79Google Scholar
  7. Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW (1987) Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors. Proc Natl Acad Sci USA 84:5153–5157Google Scholar
  8. Hammond GL, Smith CL, Paterson NAM, Sibbald WJ (1990) A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils. J Clin Endocrinol Metab 71:34–39Google Scholar
  9. Hunt LT, Dayhoff MO (1980) A surprising new protein superfamily containing ovalbumin, antithrombin III, and alpha1-proteinase inhibitor. Biochem Biophys Res Commun 95:864–871Google Scholar
  10. Keyeux G, Gilgenkrantz S, Lefranc G, Lefranc MP (1989) Molecular characterization of a ring chromosome 14 showing that the PI locus is centromeric to the D14S1 and IGH loci. Hum Genet 82:219–222Google Scholar
  11. Lohrenz FN, Seal US, Doe RP (1967) Adrenal function and serum protein concentrations in a kindred with decreased corticosteroid-binding globulin (CBG) concentration. J Clin Endocrinol Metab 27:966–972Google Scholar
  12. Mattei MG, Philip N, Passage E, Moisan JP, Mandel JL, Mattei JF (1985) DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome. Hum Genet 69:268–271Google Scholar
  13. Rabin M, Watson M, Kidd V, Woo SL, Breg WR, Ruddle FH (1986) Regional location of alpha1-antichymotrypsin and alpha1-antitrypsin genes on human chromosome 14. Somat Cell Mol Genet 12:209–214Google Scholar
  14. Rosner W (1990) The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocrinol Rev 11:80–91Google Scholar
  15. Savu L, Lombart C, Nunez EA (1980) Corticosterone binding globulin: an acute phase “negative” protein in the rat. FEBS Lett 113:102–106Google Scholar
  16. Schroeder WT, Miller MF, Woo SLC, Saunders GF (1985) Chromosomal localization of the human α1-antitrypsin gene (PI) to 14q31–32. Am J Hum Genet 37:868–872Google Scholar
  17. Siiteri PK, Murai JT, Hammond GL, Nisker JA, Raymoure WJ, Kuhn RW (1982) The serum transport of steroid hormones. Recent Prog Horm Res 38:457–510Google Scholar
  18. Testa JR (1990) Chromosome translocations in human cancer. Cell Growth Differ 1:97–101Google Scholar
  19. Travis J, Salvesen GS (1983) Human plasma proteinase inhibitors. Annu Rev Biochem 52:655–709Google Scholar
  20. Underhill DA, Hammond GL (1989) Organization of the human corticosteroid binding globulin gene and analysis of its 5′-flanking region. Mol Endocrinol 3:1448–1454Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Gilles-Eric Seralini
    • 1
  • Dominique Bérubé
    • 2
  • Richard Gagné
    • 2
  • Geoffrey L. Hammond
    • 1
  1. 1.Departments of Obstetrics and Gynecology, Oncology and BiochemistryUniversity of Western OntarioLondonCanada
  2. 2.Department of Molecular Genetics, Research CentreLaval University Medical CentreQuebecCanada
  3. 3.Department of Molecular EndocrinologyCHUL Research CentreQuebecCanada
  4. 4.London Regional Cancer CentreLondonCanada

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