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Human Genetics

, Volume 87, Issue 2, pp 189–192 | Cite as

The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic cell hybrids using the polymerase chain reaction

  • Dunne Fong
  • David I. Smith
  • Wang-Ting Hsieh
Original Investigations

Summary

Kinins, peptide products of kininogens, may be involved in hypertensive and diabetic diseases, and inflammatory disorders. The human kininogen gene (KNG) has been mapped to chromosome 3, using a panel of human-hamster somatic cell hybrids by polymerase chain reaction of hybrid DNA with gene-specific primers. KNG was further assigned to 3q26-3qter, using DNA from a second panel of chromosome 3 deletion mapping cell hybrids.

Keywords

Peptide Polymerase Chain Reaction Internal Medicine Metabolic Disease Somatic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abrahamson M, Islam MQ, Szpirer J, Szpirer C, Levan G (1989) The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20. Hum Genet 82:223–226Google Scholar
  2. Barrett AJ (1987) The cystatins: a new class of peptidase inhibitors. Trends Biochem Sci 12:193–196Google Scholar
  3. Barrett AJ, Salvesen G (eds) (1986) Proteinase inhibitors. Elsevier, AmsterdamGoogle Scholar
  4. Carlock LC, Smith DI, Wasmuth J (1986) Genetic counterselective procedure to isolate interspecific-cell hybrids containing single human chromosomes: construction of cell hybrids and recombinant DNA libraries specific for human chromosomes 3 and 4. Somat Cell Mol Genet 12:163–174Google Scholar
  5. Chan MM, Fong D (1988) Expression of human cathepsin B protein in Escherichia coli. FEBS Lett 239:219–222Google Scholar
  6. Drabkin H, Jonsen M, Wright M, Varkony T, Jones C, Sage M, Gold S, Morse H, Mendez M, Erickson P (1990) Development of a somatic cell hybrid mapping panel and molecular probes for human chromosome 3. Genomics 8:435–446Google Scholar
  7. Evans BA, Yun ZX, Close JA, Tregear GW, Kitamura N, Nakanishi S, Callen DF, Baker E, Hyland VJ, Sutherland GR, Richards RI (1988) Structure and chromosomal localization of the human renal kallikrein gene. Biochemistry 27:3124–3129Google Scholar
  8. Fong D, Calhoun DH, Hsieh WT, Lee B, Wells RD (1986) Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B. Proc Natl Acad Sci USA 83:2909–2913Google Scholar
  9. Fong D, Kartasova T, Sloane BF, Chan MM (1989) Bacterial expression of human cysteine proteinase inhibitor stefin A. FEBS Lett 257:55–58Google Scholar
  10. Fujikawa K, Saito H (1989) Contact activation. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherited disease II. McGraw-Hill, New York, pp 2189–2206Google Scholar
  11. Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (1988) Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. Am J Hum Genet 43:442–451Google Scholar
  12. Hsieh WT, Fong D, Sloane BF, Golembieski W, Smith DI (1991) Mapping of the gene for human cysteine proteinase inhibitor stefin A, STF1, to chromosome 3cen-q21. Genomics 9:207–209Google Scholar
  13. Innis MA, Gelfand DH, Sninsky JJ, White TJ (eds) (1990) PCR protocols. Academic Press, San DiegoGoogle Scholar
  14. Kitamura N, Kitagawa H, Fukushima D, Takagaki Y, Miyata T, Nakanishi S (1985) Strucutral organization of the human kininogen gene and a model for its evolution. J Biol Chem 260:8610–8617Google Scholar
  15. Kouri RE, Lewis M, Barker DF, Dietz-Band JN, Nguyen KN, McLemore T, Wasmuth JJ (1989) Mapping 14 human gene sequence with a commercially available somatic cell hybrid panel. Cytogenet Cell Genet 51:1025Google Scholar
  16. Margolius HS (1989) Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases. Annu Rev Pharmacol Toxicol 29:343–364Google Scholar
  17. Moin K, Rozhin J, McKernan TB, Sanders VJ, Fong D, Honn KV, Sloane BF (1989) Enhanced levels of cathepsin B mRNA in murine tumors. FEBS Lett 244:61–64Google Scholar
  18. Nakanishi S (1987) Substance P precursor and kininogen: their structures, gene organization, and regulation. Physiol Rev 67:1117–1142Google Scholar
  19. Neurath H (1989) The diversity of proteolytic enzymes. In: Beynon RJ, Bond JS (eds) Proteolytic enzymes: a practical approach. IRL, Oxford, pp 1–13Google Scholar
  20. Ohkubo I, Kurachi K, Takasawa T, Shiokawa H, Sasaki M (1984) Isolation of a human cDNA for α2-thiol proteinase inhibitor and its identity with low molecular weight kininogen. Biochemistry 23:5691–5697Google Scholar
  21. Proud D, Kaplan AP (1988) Kinin formation: mechanisms and role in inflammatory disorders. Annu Rev Immunol 6:49–83Google Scholar
  22. Rawlings ND, Barrett AJ (1990) Evolution of proteins of the cystatin superfamily. J Mol E vol 30:60–71Google Scholar
  23. Saitoh E, Sabatini LM, Eddy RL, Shows TB, Azen EA, Isemura S, Sanada K (1989) The human cystatin C gene (CST3) is a member of the cystatin gene family which is localized on chromosome 20. Biochem Biophys Res Commun 162:1324–1331Google Scholar
  24. Takagaki Y, Kitamura N, Nakanishi S (1985) Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. J Biol Chem 260:8601–8609Google Scholar
  25. Turk V (ed) (1988) Cysteine proteinases and their inhibitors. Gruyter, BerlinGoogle Scholar
  26. Van den Berg EA, Clercq E le, Kluft C, Koide T, Zee A van der, Oldenburg M, Wijnen JT, Kahn PM (1990) Assignment of the human gene for histidine-rich glycoprotein to chromosome 3. Genomics 7:276–279CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Dunne Fong
    • 1
  • David I. Smith
    • 2
  • Wang-Ting Hsieh
    • 3
  1. 1.Department of Biological Sciences and Bureau of Biological Research, Rutgers, The State University of New JerseyC226 Nelson Biological LaboratoriesPiscatawayUSA
  2. 2.Department of Molecular Biology and GeneticsWayne State University School of MedicineDetroitUSA
  3. 3.Clinical Neurogenetics BranchNational Institute of Mental HealthBethesdaUSA

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