Journal of Molecular Medicine

, Volume 74, Issue 1, pp 13–33 | Cite as

Intercellular adhesion molecule-1

  • A. van de Stolpe
  • P. T. van der Saag


The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells. It can be induced in a cell-specific manner by several cytokines, for example, tumor necrosis factor-α, interleukin-1, and interferon-γ, and inhibited by glucocorticoids. Its ligands are the membrane-bound integrin receptors LFA-1 and Mac-1 on leukocytes, CD43, the soluble molecule fibrinogen, the matrix factor hyaluronan, rhinoviruses, and Plasmodium falciparum malaria-infected erythrocytes. ICAM-1 expression is predominantly transcriptionally regulated. The ICAM-1 promoter contains several enhancer elements, among them a novel κB element which mediates effects of 12-O-tetradecanoylphorbol-13-acetate, interleukin-1, lipopolysaccharide, tumor necrosis factor-α, and glucocorticoids. Expression regulation is cell specific and depends on the availability of cytokine/hormone receptors, signal transduction pathways, transcription factors, and posttranscriptional modification. ICAM-1 plays a role in inflammatory processes and in the T-cell mediated host defense system. It functions as a costimulatory molecule on antigen-presenting cells to activate MHC class II restricted T-cells, and on other cell types in association with MHC class I to activate cytotoxic T-cells. ICAM-1 on endothelium plays an important role in migration of (activated) leukocytes to sites of inflammation. ICAM-1 is shed by the cell and detected in plasma as sICAM-1. Regulation and significance of s-lCAM-1 are as yet unclear, but sICAM-1 is increased in many pathological conditions. ICAM-1 may play a pathogenetic role in rhinovirus infections. Derangement of ICAM-1 expression probably contributes to the clinical manifestations of a variety of diseases, predominantly by interfering with normal immune function. Among these are malignancies (e.g., melanoma and lymphomas), many inflammatory disorders (e.g., asthma and autoimmune disorders), atherosclerosis, ischemia, certain neurological disorders, and allogeneic organ transplantation. Interference with ICAM-1 leukocyte interaction using mAbs, soluble ICAM-1, antisense ICAM-1 RNA, and in the case of melanoma mAb-coupled immunotoxin, may offer therapeutic possibilities in the future. Integration of knowledge concerning membrane-bound and soluble ICAM-1 into a single functional system is likely to contribute to elucidating the immunoregulatory function of ICAM-1 and its pathophysiological significance in various disease entities.

Key words

Adhesion Intercellular adhesion molecule-1 Inflammation Malignancy 



Intercellular adhesion molecule






Leukocyte function associated antigen


Monoclonal antibody


Membrane-bound ICAM-1


Nuclear factor


Non-Hodgkin lymphoma


Retinoic acid receptor


Soluble ICAM-1


Tumor necrosis factor




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  1. 1.
    Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67:1033–1036Google Scholar
  2. 2.
    Dustin ML (1990) Two-way signalling through the LFA-1 lymphocyte adhesion receptor. Bioessays 12:421–427Google Scholar
  3. 3.
    Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434Google Scholar
  4. 4.
    Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451–1455Google Scholar
  5. 5.
    Staunton DE, Dustin ML, Springer TA (1989) Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 339:61–64Google Scholar
  6. 6.
    Fawcett J, Holness CLL, Needham LA, Turley H, Garter KC, Mason DY, Simmons DL (1992) Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Nature 360:481–484Google Scholar
  7. 7.
    Fougerolles AR de, Springer TA (1992) Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med 175:185–190Google Scholar
  8. 8.
    Vazeux R, Hoffman PA, Tomita JK, Dickinson ES, Jasman RL, St John T, Gallatin WM (1992) Cloning and characterization of a new intercellular adhesion molecule ICAM-R. Nature 360:485–488Google Scholar
  9. 9.
    Simmons D, Makgoba MW, Seed B (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331:624–627Google Scholar
  10. 10.
    Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj S, Chi-Rosso G, Lobb R (1989) Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203–1211Google Scholar
  11. 11.
    Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (1990) PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247:1219–1222Google Scholar
  12. 12.
    Binnerts ME, van Kooyk Y, Simmons DL, Figdor CG (1994) Distinct binding of T lymphocytes to ICAM-1, -2 or -3 upon activation of LFA-1. Eur J Immunol 24:2155–2160Google Scholar
  13. 13.
    Albelda SM, Buck CA (1990) Integrins and other cell adhesion molecules. FASEB J 4:2868–2880PubMedGoogle Scholar
  14. 14.
    Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA (1986) Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137:245–254Google Scholar
  15. 15.
    Rothlein R, Dustin ML, Marlin SD, Springer TA (1986) A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137:1270–1274Google Scholar
  16. 16.
    Dougherty GJ, Murdoch S, Hogg N (1988) The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response. Eur J Immunol 18:35–39Google Scholar
  17. 17.
    Boyd AW, Dunn SM, Fecondo JV, Culvenor JG, Dührsen U, Burns GF, Wayryk SO (1989) Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation. Blood 73:1896–1903Google Scholar
  18. 18.
    Dustin ML, Springer TA (1989) T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619–624Google Scholar
  19. 19.
    Sligh JE, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A, Beaudet AL (1993) Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule-1. Proc Natl Acad Sci USA 90:8529–8533Google Scholar
  20. 20.
    Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, Gutierrez-Ramos JC (1994) Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med 180:95–109Google Scholar
  21. 21.
    Siu G, Hedrick SM, Brian AA (1989) Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. J Immunol 143:3813–3820Google Scholar
  22. 22.
    Kita Y, Takashi T, Iigo Y, Tamatani T, Miyasaki M, Horiuchi T (1992) Sequence and expression of rat ICAM-1. Biochim Bioph Acta 1131:108–110Google Scholar
  23. 23.
    Manning AM, Lu HF, Kukielka GL, Oliver MG, Ty T, Toman CA, Drong RF, Slightom JL, Ballantyne CM, Entman ML, Smith CW, Anderson DC (1995) Cloning and comparative sequence analysis of the gene encoding canine intercellular adhesion molecule-1 (ICAM-1). Gene 156:291–295Google Scholar
  24. 24.
    Voraberger G, Schäfer R, Stratowa C (1991) Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. J Immunol 147:2777–2786Google Scholar
  25. 25.
    Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA (1988) Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52:925–933Google Scholar
  26. 26.
    Staunton DE, Dustin ML, Erickson HP, Springer TA (1990) The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 61:243–254Google Scholar
  27. 27.
    Giranda VL, Chapman MS, Rossmann MG (1990) Modeling of the human intercellular adhesion molecule-1, the human rhinovirus major group receptor. Proteins 7:227–233Google Scholar
  28. 28.
    Marlin SD, Springer TA (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51:813–819CrossRefPubMedGoogle Scholar
  29. 29.
    Carpén O, Pallai P, Staunton DE, Springer TA (1992) Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and α-actinin. J Cell Biol 118:1223–1234Google Scholar
  30. 30.
    Dustin ML, Carpen O, Springer TA (1992) Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors. J Immunol 148:2654–2663Google Scholar
  31. 31.
    Vignola AM, Chanez P, Campbell AM, Pinel AM, Bousquet J, Michel FB, Godard PH (1994) Quantification and localization of HLA-DR and intercellular adhesion molecule-1 (ICAM-1) molecules on bronchial epithelial cells of asthmatics using confocal microscopy. Clin Exp Immunol 96:104–110Google Scholar
  32. 32.
    Sanders VM, Vitetta ES (1991) B cell-associated LFA-1 and T cell-associated ICAM-1 transiently cluster in the area of contact between interacting cells. Cell Immunol 132:45–55Google Scholar
  33. 33.
    Stolpe A van de, Jacobs N, Hage WJ, Tertoolen L, Kooyk Y van, Nováková IRQ, Witte T de (1996) Fibrinogen-binding to intercellular adhesion molecule-1 on EA.hy 926 endothelial cells is dependent on an intact cytoskeleton. Thromb Haemost (in press)Google Scholar
  34. 34.
    Diamond MS, Staunton DE, de Fougerolles AR, Stacker SA, Garcia-Aguilar J, Hibbs ML, Springer TA (1990) ICAM-1 (CD54): a counter-receptor for Mac-1 (CDllb/CD18). J Cell Biol 111:3129–3139Google Scholar
  35. 35.
    Diamond MS, Staunton DE, Marlin SD, Springer TA (1991) Binding of the integrin Mac-1 (GD11b/CD18) to the third immunoglobulin-like of ICAM-1 (CD54) and its regulation by glycosylation. Cell 65:961–971Google Scholar
  36. 36.
    Diamond MS, Springer TA (1993) A subpopulation of Mac-1 (CDllb/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol 120:545–556Google Scholar
  37. 37.
    Remold-O'Donnell E, Zimmerman C, Kenney D, Rosen FS (1987) Expression on blood cells of sialophorin, the surface glycoprotein that is defective in Wiskott-Aldrich syndrome. Blood 70:104–109Google Scholar
  38. 38.
    Rosenstein Y, Park JK, Hahn WC, Rosen FS, Bierer BE, Burakoff SJ (1991) CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature 354:233–235Google Scholar
  39. 39.
    Fougerolles AR de, Qin X, Springer TA (1994) Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses. J Exp Med 179:619–629Google Scholar
  40. 40.
    Fecondo JV, Kent SBH, Boyd AW (1991) Inhibition of intercellular adhesion molecule 1-dependent biological activities by a synthetic peptide analog. Proc Natl Acad Sci USA 88:2879–2882Google Scholar
  41. 41.
    Bloemen P, Moldenhauer G, van Dijk M, Schuurman HJ, Bloem AC (1992) Multiple ICAM-1 (CD54) epitopes are involved in homotypic B-cell adhesion. Scand J Immunol 35:517–523Google Scholar
  42. 42.
    Stanley P, Bates PA, Harvey J, Bennett RI, Hogg N (1994) Integrin LFA-1 α subunit contains an ICAM-1 binding site in domains V and VI. EMBO J 13:1790–1798Google Scholar
  43. 43.
    Languino LR, Plescia J, Duperray A, Brian AA, Plow EF, Geltosky JE, Altieri DC (1993) Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 73:1423–1434Google Scholar
  44. 44.
    McCourt PAG, Ek B, Forsberg N, Gustafson S (1994) Intercellular adhesion molecule-1 is a cell surface receptor for Hyaluronan. J Biol Chem 269:30081–30084Google Scholar
  45. 45.
    Altieri DC, Duperray A, Plescia J, Thornton GB, Languino LR (1995) Structural recognition of a novel fibrinogen γ chain sequence (117–133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction. J Biol Chem 270:696–699Google Scholar
  46. 46.
    Languino LR, Duperray A, Joganic KJ, Fornaro M, Thornton GB, Altieri DC (1995) Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. Proc Natl Acad Sci USA 92:1505–1509Google Scholar
  47. 47.
    Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, Marlor CW, Kamarck ME, McClelland A (1989) The major human rhinovirus receptor is ICAM-1. Cell 56:839–847Google Scholar
  48. 48.
    Staunton DE, Merluzzi, R., Rothlein, R. Barton, S.D. Marlin, T.A. Springer (1989) A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell 56:849–853Google Scholar
  49. 49.
    Tomassini JE, Graham D, DeWitt CM, Lineberger DW, Rodkey JA, Colonno RJ (1989) cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule-1. Proc Natl Acd Sci USA 86:4907–4911Google Scholar
  50. 50.
    Marlin SD, Staunton DE, Springer TA, Stratowa C, Sommergruber W, Merluzzi VJ (1990) A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection. Nature 344:70–72Google Scholar
  51. 51.
    Berendt AR, Simmons DL, Tansey J, Newbold CI, Marsh K (1989) Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature 341:57–59Google Scholar
  52. 52.
    Ockenhouse CF, Ho M, Tandon NN, van Seventer GA, Shaw S, White NJ, Jamieson GA, Chulay JD, Webster HK (1991) Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Inf Dis 164:163–169Google Scholar
  53. 53.
    Ockenhouse CF, Betageri R, Springer TA, Staunton DE (1992) Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1 and human rhinovirus. Cell 68:63–69Google Scholar
  54. 54.
    Kooyk Y van, van Kemenade PV, Weder P, Kuijpers TW, Figdor CG (1989) Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 342:811–813Google Scholar
  55. 55.
    Hibbs ML, Xu H, Stacker SA, Springer TA (1991) Regulation of adhesion to ICAM-1 by the cytoplasmic domain of LFA-1 integrin β subunit. Science 251:1611–1613Google Scholar
  56. 56.
    Cabanas C, Hogg N (1993) Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1. Proc Natl Acad Sci USA 90:5838–5842Google Scholar
  57. 57.
    Kooyk Y van, Weder P, Heye K, Figdor CG (1994) Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion. J Cell Biol 124:1061–1070Google Scholar
  58. 58.
    Campanero M R, del Pozo MA, Arroyo AG, Sanchez-Mateos P, Hernández-Caselles T, Craig A, Pulido R, Sánchez-Madrid F (1993) ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J Cell Biol 123:1007–1016Google Scholar
  59. 59.
    Lorentz HM, Lagoo AS, Hardy KJ (1994) The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion. Blood 83:1862–1870Google Scholar
  60. 60.
    Niu XF, Smith CW, Kubes P (1994) Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res 74:1133–1140Google Scholar
  61. 61.
    Sellak H, Franzini E, Hakim J, Pasquier C (1994) Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation. Blood 83:2669–2677Google Scholar
  62. 62.
    Martin S, Martin A, Staunton DE, Springer TA (1993) Functional studies of truncated soluble intercellular adhesion molecule-1 expressed in Escherichia coli. Antimicrob Agents Chemother 37:1278–1285Google Scholar
  63. 63.
    Hanasaki K, Varki A, Stamenkovich I, Bevilacqua MP (1994) Cytokine-induced β-galactoside α2,6-sialytransferase in human endothelial cells mediates α2,6-sialylation of adhesion molecules and CD22 ligands. J Biol Chem 269:10637–10643Google Scholar
  64. 64.
    Liesveld JL, Dipersio JF, Abboud CN (1994) Integrins and adhesive receptors in normal and leukemic CD34+ progenitor cells: potential regulatory checkpoints for cellular traffic. Leuk Lymphoma 14:19–28Google Scholar
  65. 65.
    Clark EA, Ledbetter JA, Holly RC, Dinndorf PA, Shu G (1986) Polypeptides on human B lymphocytes associated with cell activation. Hum Immunol 16:100–105Google Scholar
  66. 66.
    Buckle AM, Hogg N (1990) Human memory T cells express intercellular adhesion molecule-1 which can be increased by interleukin 2 and interferon-γ. Eur J Immunol 20:337–341Google Scholar
  67. 67.
    Maio M, Pinto A, Carbone A, Zagonel V, Gloghini A, Marotta G, Cirillo D, Colombatti A, Ferrara F, del Vecchio L, Ferrone S (1990) Differential expression of CD54/intercellular adhesion molecule-1 in myeloid leukemias and in lymphoproliferative disorders. Blood 76:783–790Google Scholar
  68. 68.
    Arkin S, Naprstek B, Guarini L, Ferrone S, Lipton JM (1991) Expression of intercellular adhesion molecule-1 (CD54) on hematopoietic progenitors. Blood 77:948–953Google Scholar
  69. 69.
    Möst J, Schwaeble W, Dierich MP (1992) Expression of intercellular adhesion molecule-1 (ICAM-1) on human monocytes. Immunobiol 185:327–336Google Scholar
  70. 70.
    Möst J, Schwaeble W, Drach J, Sommerauer A, Dierich MP (1992) Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines. J Immunol 148:1635–1642Google Scholar
  71. 71.
    Rothlein R, Czajkowski M, O'Neill MM, Marlin SD, Mainolfi E, Merluzzi VJ (1988) Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. J Immunol 141:1665–1669Google Scholar
  72. 72.
    Myers CL, Wertheimer SJ, Schembri-King J, Parks T, Wallace RW (1992) Induction of ICAM-1 by TNF-γ, IL-1ß, and LPS in human endothelial cells after downregulation of PKC. Am J Physiol 263:C767-C772Google Scholar
  73. 73.
    Gerritsen ME, Kelly KA, Ligon G, Perry CA, Shen CP, Szczepanski A, Carley WW (1993) Regulation of the expression of intercellular adhesion molecule 1 in cultured human endothelial cells derived from rheumatoid synovium. Arthritis Rheum 36:593–602Google Scholar
  74. 74.
    Thorp KM, Southern C, Bird IN, Matthews N (1992) Tumor necrosis factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells analysis of tumor necrosis factor-receptor interactions. Cytokine 4:313–319Google Scholar
  75. 75.
    Wertheimer SJ, Myers CL, Wallace RW, Parks TP (1992) Intercellular adhesion molecule-1 gene expression in human endothelial cells. J Biol Chem 267:12030–12035PubMedGoogle Scholar
  76. 76.
    Campbell IL, Cutri A, Wilkinson D, Boyd AW, Harrison LC (1989) Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection. Proc Natl Acad Sci USA 86:4282–4286Google Scholar
  77. 77.
    Jevnikar AM, Wuthrich RP, Takei F, Xu HW, Brennan DC, Glimcher LH, Rubin-Kelly VE (1990) Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells. Kidney Int 38:417–425Google Scholar
  78. 78.
    Tosi MF, Stark JM, Smith CW, Hamedani A, Gruenert DC, Infeld MD (1992) Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: effects on neutrophil-epithelial cell adhesion. Am J Resp Cell Mol Biol 7:214–221Google Scholar
  79. 79.
    Bloemen PGM, van den Tweel MC, Henricks PAJ, Engels F, Wagenaar SS, Rutten AAJJL, Nijkamp FP (1993) Expression and modulation of adhesion molecules on human bronchial epithelial cells. Am J Respir Cell Mol Biol 9:586–593Google Scholar
  80. 80.
    Tessier P, Audette M, Cattaruzzi P, McColl SR (1993) Upregulation by tumor necrosis factor α of intercellular adhesion molecule-1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids. Arthritis Rheum 36:1528–1539Google Scholar
  81. 81.
    Kvale D, Brandtzaeg P (1993) Immune modulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human hepatocytic cell lines. J Hepatol 17:347–352Google Scholar
  82. 82.
    Mitra RS, Shimizu Y, Nickoloff BJ (1993) Histamine and cis- urocanic acid augment tumor necrosis factor-alpha mediated induction of keratinocyte intercellular adhesion molecule-1 expression. Cell Physiol 156:348–357Google Scholar
  83. 83.
    Birdsall HH, Lane C, Ramser MN, Anderson DC (1992) Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adherence. J Immunol 148:2717–2723Google Scholar
  84. 84.
    Couffinhal T, Dupláa C, Labat L, Lamaziere JMD, Moreau C, Printseva O, Bonnet J (1993) Tumor necrosis factor-α stimulates ICAM-1 expression in human vascular smooth muscle cells. Arterioscler Thromb 13:407–414Google Scholar
  85. 85.
    Couffinhal T, Dupláa C, Moreau C, Lamaziere JM, Bonnet J (1994) Regulation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular smooth muscle cells. Circ Res 74:225–234Google Scholar
  86. 86.
    Bassi V, Vitale M, Feliciello A, Deriu S, Rossi G, Fenzi G (1995) Retinoic acid induces intercellular adhesion molecule1 hyperexpression in human thyroid carcinoma cell lines. J Clin Endo Metab 80:1129–1135Google Scholar
  87. 87.
    Pober JS, Gimbrone Jr. MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA (1986) Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune Interferon. J Immunol 137:1893–1896Google Scholar
  88. 88.
    Nambu M, Mayumi M, Mikawa H (1992) Regulation of the expression of leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) on a human eosinophilic leukemia cell line eol-3. Cell Immunol 143:335–347Google Scholar
  89. 89.
    Ibrahim L, Dominquez M, Yacoub M (1993) Primary human adult lung epithelial cells in vitro: response to interferon-γ and cytomegalovirus. Immunol 79:119–124Google Scholar
  90. 90.
    Piela-Smith TH, Broketa G, Hand A, Kprn JH (1992) Regulation of ICAM-1 expression and function in human dermal fibrolasts by IL-4. J Immunol 148:1375–1381Google Scholar
  91. 91.
    Willems F, Marchant A, Delville JP, Gérard C, Delvaux A, Velu T, de Boer M, Goldman M (1994) Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 24:1007–1009Google Scholar
  92. 92.
    Beekhuizen H, Verdegaal EME, Blokland I, van Furth R (1992) Contribution of ICAM-1 and VCAM-1 to the morphological changes in monocytes bound to human venous endothelial cells stimulated with recombinant interleukin-4 (rlL-4) or rIL-lα. Immunol 77:469–472Google Scholar
  93. 93.
    Czech W, Krutmann J, Budnik A, Schöpf E, Kapp A (1993) Induction of intercellular adhesion molecule 1 (ICAM-1) expression in normal human eosinophils by inflammatory cytokines. J Invest Dermatol 100:417–423Google Scholar
  94. 94.
    Hansel TT, de Vries UM, Carballido JM, Braun RK, Carballido-Perrig N, Rihs S, Blaser K, Walker C (1992) Induction and function of eosinophil intercellular adhesion molecule-1 and HLA-DR. J Immunol 149:2130–2136Google Scholar
  95. 95.
    Brändén H, Lundgren E (1993) Differential regulation of LFA-1 and ICAM-1 on human primary B-lymphocytes. Cell Immunol 147:64–72Google Scholar
  96. 96.
    Valent P, Bevec D, Maurer D, Besemer J, di Padova F, Butterfield JH, Speiser W, Majdic O, Lechner K, Bettelheim P (1991) Interleukin 4 promotes expression of mast cell ICAM-1 antigen. Proc Natl Acad Sci USA 88:3339–3342Google Scholar
  97. 97.
    Ohteki T, Okamoto S, Nakamura M, Nemoto E, Kumagai K (1993) Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/1pr mice. Immunol Lett 36:145–152Google Scholar
  98. 98.
    Palmblad JEW, Lerner R (1992) Leukotriene B4-induced hyperadhesiveness of endothelial cells for neutrophils: Relation to CD54. Clin Exp Immunol 90:300–304Google Scholar
  99. 99.
    Sugama Y, Tiruppathi C, Janakidevi K, Andersen TT, Fenton II JW, Malik AB (1992) Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion. J Cell Biol 119:935–944Google Scholar
  100. 100.
    McCarron RM, Wang L, Stanimirovic DB, Spatz M (1993) Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells. Neurosci Letters 156:31–34Google Scholar
  101. 101.
    Morisaki N, Takahashi K, Shiina R, Zenibayashi M, Otabe M, Yoshida S, Salto Y (1994) Platelet-derived growth factor is a potent stimulator of expression of intercellular adhesion molecule-1 in human arterial smooth muscle cells. Biochem Biophys Res Commun 200:612–618Google Scholar
  102. 102.
    Nakagawa N, Iwamoto I, Yoshida S (1993) Effect of substance P on the expression of an adhesion molecule ICAM-1 in human vascular endothelial cells. Regul Peptides 46:223–224Google Scholar
  103. 103.
    Bendall LJ, Kortlepel K, Gottlieb DJ (1995) GM-CSF enhances IL-2-activated natural killer celll lysis of clonogenic AML cells by upregulating target cell expression of ICAM-1. Leukemia 9:677–684Google Scholar
  104. 104.
    Darley R, Morris A, Passas J, Bateman W (1993) Interactions between interferon γ and retinoic acid with transforming growth factor β in the induction of immune recognition molecules. Cancer Immunol Immunother 37:112–118Google Scholar
  105. 105.
    Bouillon M, Fortier MA, Boulianne R, Audette M (1992) Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon γ. Int J Cancer 50:281–288Google Scholar
  106. 106.
    Bouillon M, Audette M (1993) Transduction of retinoic acid and γ-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation. Cancer Res 33:826–832Google Scholar
  107. 107.
    Cilenti L, Toniato E, Ruggiero P, Fusco C, Farina AR, Tiberio A, Hayday AC, Gulino A, Frati L, Martinotti S (1995) Transcriptional modulation of the human intercellular adhesion molecule gene 1 (ICAM-1) by retinoic acid in melanoma cells. Exp Cell Res 218:263–270Google Scholar
  108. 108.
    Aoudjit F, Bossé M, Stratowa C, Voraberger G, Audette M (1994) Regulation of intercellular adhesion molecule-1 expression by retinoic acid: analysis of the 5' regulatory region of the gene. Int J Cancer 58:543–549Google Scholar
  109. 109.
    Bouillon M, Tessier P, Boulianne R, Destrempe R, Audette M (1991) Regulation by retinoic acid of ICAM-1 expression on human tumor cell lines. Biochim Biophys Acta 1097:95–102Google Scholar
  110. 110.
    Cid MC, Kleinman HK, Grant DS, Schnaper HW, Fauci AS, Hoffman GS (1994) Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J Clin Invest 93:17–25Google Scholar
  111. 111.
    Dorp WT van, Wieringen PAM van, Marselis-Jonges E, Bruggeman CA, Daha MR, Es LA van, Woude FJ van der (1993) Cytomegalovirus directly enhances MHC class 1 and intercellular adhesion molecule-1 expression on cultured proximal tubular epithelial cells. Transplantation 55:1367–1371Google Scholar
  112. 112.
    Tosi MF, Stark JM, Hamedani A, Smith CW, Gruenert DC, Huang YT (1993) Intercellular adhesion molecule-1 (ICAM-1)-dependent adhesive interactions between polymorphonuclear leukocytes and human airway epithelial cells infected with parainfluenza virus type 2. J Immunol 149:3345–3349Google Scholar
  113. 113.
    Nagel T, Atkinson WJ, Dewey CF, Gimbrone Jr MA (1994) Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest 94:885–891Google Scholar
  114. 114.
    Tsuboi H, Ando J, Korenaga R, Takada Y, Kamiya A (1995) Flow stimulates ICAM-1 expression time and shear stress dependently in cultured human endothelial cells. Biochem Biophys Res Commun 206:988–996Google Scholar
  115. 115.
    Heckmann M, Eberlein-König B, Wollenberg A, Przybilla A, Plewig G. (1994) Ultraviolet-A radiation induces adhesion molecule expression on human dermal microvascular endothelial cells. Br J Dermatol 131:311–318Google Scholar
  116. 116.
    Ritchie AJ, Johnson DR, Ewenstein BM, Pober JS (1991) Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. J Immunol 146:3056–3062Google Scholar
  117. 117.
    Stolpe A van de, Caldenhoven E, Raaijmakers JAM, Saag PT van der, Koenderman L (1993) Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am J Respir Cell Mol Biol 8:340–347Google Scholar
  118. 118.
    Vignola AM, Campbell AM, Chanez P, Lacoste P, Michel FB, Godard P, Bousquet J (1993) Activation by histamine of bronchial epithelial cells from nonasthmatic subjects. Am J Respir Cell Mol Biol 9:411–417Google Scholar
  119. 119.
    Palkama T, Majuri ML, Mattila P, Hurme M, Renkonen R (1993) Regulation of endothelial adhesion molecules by ligands binding to the scavenger receptor. Clin Exp Immunol 92:353–360Google Scholar
  120. 120.
    Sugiyama S, Kugiyama K, Ohgushi M, Fujimoto K, Yasue H (1994) Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries. Circ Res 74:565–575Google Scholar
  121. 121.
    Goebeler M, Meinardus-Hager G, Roth J, Goerdt S, Sorg C (1993) Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells. J Invest Dermatol 100:759–765Google Scholar
  122. 122.
    Lo SK, Janakidevi K, Lai L, Malik AB (1993) Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation. Am J Physiol 264:L406-L412Google Scholar
  123. 123.
    Renkonen R, Mattila P, Majuri M-L, Paavonen T, Silvennoinen (1992) IL-4 decreases IFN-γ-induced endothelial ICAM-1 expression by a transcriptional mechanism. Scand J Immunol 35:525–530Google Scholar
  124. 124.
    Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G (1992) A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 89:9991–9995Google Scholar
  125. 125.
    Guida L, Ohehir RE, Hawrylowicz CM (1994) Synergy between dexamethasone and interleukin-5 for the induction of major histocompatability complex class II expression by human peripheral blood eosinophils. Blood 84:2733–2740Google Scholar
  126. 126.
    Hiromatsu Y, Sato M, Yamada K, Nonaka K. (1991) Inhibitory effects of nicotinamide on recombinant human interferon-γ-induced intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigen expression on cultured human endothelial cells. Immunol Lett 31:35–39Google Scholar
  127. 127.
    Hiromatsu Y, Sato M, Tanaka K, Ishisaka N, Kamachi J, Nonaka K (1993) Inhibitory effects of nicotinamide on intercellular adhesion molecule-1 expression on cultured human thyroid cells. Immunol 80:330–332Google Scholar
  128. 128.
    Stuhlmeyer KM, Csizmadia V, Cheng G, Winkler H, Bach FH (1994) Selective inhibition of E-selectin, ICAM-1 and VCAM in endothelial cells. Eur J Immunol 24:2186–2190Google Scholar
  129. 129.
    Stolpe A van de, Caldenhoven E, Stade BG, Koenderman L, Raaijmakers JAM, Johnson JP, Saag PT van der (1994) 12-O-Tetradecanoylphorbol-13-acetate-and tumor necrosis factor α-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone: functional analysis of the human intercellular adhesion molecule-1 promoter. J Biol Chem 269:6185–6192Google Scholar
  130. 130.
    Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R (1994) Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proc Natl Acad Sci USA 91:3994–3998Google Scholar
  131. 131.
    Gerritsen ME, Niedbala MJ, Szczepanski A, Carley WW (1993) Cytokine activation of human macro-and microvessel-derived endothelial cells. Blood Cells 19:325–342Google Scholar
  132. 132.
    Jahnke A, van de Stolpe A, Caldenhoven E, Johnson JP (1995) Constitutive expression of human intercellular adhesion molecule-1 (ICAM-1) is regulated by differentially active enhancing and silencing elements. Eur J Biochem 228:439–446Google Scholar
  133. 133.
    Cornelius LA, Taylor JT, Degitz K, Li LJ, Lawley TJ, Wright Caughman S (1993) A 5′ portion of the ICAM-1 gene confers tissue-specific differential expression levels and cytokine responsiveness. J Invest Dermatol 100:753–758Google Scholar
  134. 134.
    Look DC, Pelletier MR, Holtzman MJ (1994) Selective interaction of a subset of interferon-γ response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells. J Biol Chem 269:8952–8958Google Scholar
  135. 135.
    Scheynius A, Engstrand L (1991) Gastric epithelial cells in Helicobacter pylory-associated gastritis express HLA-DR but not ICAM-1. Scand J Immunol 33:237–241Google Scholar
  136. 136.
    Dean NM, McKay R, Condon TP, Bennett CF (1994) Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J Biol Chem 269:16416–16424Google Scholar
  137. 137.
    Pober JS, Slowik MR, de Luca LG, Ritchie AJ (1993) Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. J Immunol 150:5114–5123Google Scholar
  138. 138.
    Renkonen R, Mennander A, Ustinov J, Mattila P (1990) Activation of protein kinase C is crucial in the regulation of ICAM-1 expression on endothelial cells by interferon-γ. Int Immunol 2:719–724Google Scholar
  139. 139.
    Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T (1995) The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity 2:493–506Google Scholar
  140. 140.
    Kurose I, Kubes P, Wolf RE, Anderson DC, Paulson J, Miyasaka M, Granger DN (1993) Inhibition of nitric oxide production: mechanisms of vascular albumin leakage. Circ Res 73:164–171Google Scholar
  141. 141.
    Tiisala S, Majuri M-L, Carpen O, Renkonen R (1994) Genistein enhances the ICAM-mediated adhesion by inducing the expression of ICAM-1 and its counter-receptors. Biochem Biophys Res Commun 203:443–449Google Scholar
  142. 142.
    Abe Y, Gatanaga M, Osuka Y, Kimura S, Burger RA, Granger GA, Gatanaga T (1993) Role of 55-and 75-kDa tumor necrosis factor membrane receptors in the regulation of intercellular adhesion molecules-1 expression by HL-60 human promyelocytic leukemia cells in vitro. J Immunol 150:5070–5079Google Scholar
  143. 143.
    Stade BG, Messer G, Riethmüller G, Johnson JP (1990) Structural characteristics of the 5′ region of the human ICAM-1 gene. Immunobiol 182:79–87Google Scholar
  144. 144.
    Degitz K, Lian-Jie L, Wright Caughman S (1991) Cloning and characterization of the 5′ transcriptional regulatory region of the human intercellular adhesion molecule 1 gene. J Biol Chem 266:14024–14030Google Scholar
  145. 145.
    Wawryk SO, Cockerill PN, Wicks IP, Boyd AW (1991) Isolation and characterization of the promoter region of the human intercellular adhesion molecule-1 gene. Int Immunol 3:83–93Google Scholar
  146. 146.
    Ballantyne CM, Sligh Jr JE, Dai XY, Beaudet AL (1992) Characterization of the murine ICAM-1 gene. Genomics 14:1076–1080Google Scholar
  147. 147.
    Puch BF, Tjian R (1990) Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61:1187–1197Google Scholar
  148. 148.
    Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M (1987) Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729–739Google Scholar
  149. 149.
    Caldenhoven E, Coffer P, Yuan J, van de Stolpe A, Horn F, Kruijer W, van der Saag PT (1994) Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-γ involves binding of distinct factors to a palindromic response element. J Biol Chem 269:21146–21154Google Scholar
  150. 150.
    Hou J, Baichwal V, Cao Z (1994) Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellar adhesion molecule 1. Proc Natl Acad Sci USA 91:11641–11645Google Scholar
  151. 151.
    Jahnke A, Johnson JP (1994) Synergistic activation of inter-cellular adhesion molecule 1 (ICAM-1) by TNF-α and IFN-γ is mediated by p65/p50 and p65/c/rel and interferon-responsive factor statlα (p91) that can be activated by both IFN-γ and IFN-α. FEBS Lett 354:220–226Google Scholar
  152. 152.
    Yuan J, Wegenka UM, Lütticken C, Buschmann J, Decker T, Schindler C, Heinrich PC, Horn F (1994) The signalling pathways of interleukin-6 and γ interferon converge by the activation of different transcription factors which bind to common responsive DNA elements. Mol Cell Biol 14:1657–1668Google Scholar
  153. 153.
    Weber C, Calzada-Wack JC, Goretzki M, Pietsch A, Johnson JP, Ziegler-Heitbrock HWL (1995) Retinoic acid inhibits basal and interferon-γ induced expression of intercellular adhesion molecule 1 in monocytic cells. J Leukocyte Biol 57:401–406Google Scholar
  154. 154.
    Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey Jr CF, Gimbrone Jr MA (1993) Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci USA 90:4591–4595Google Scholar
  155. 155.
    Grether-Beck S, Gyufko K, Klammer M, Jahnke A, Johnson JP (1995) Identification of the ultraviolet A1 radiation/singlet oxygen responsive element of the human ICAM-1 gene. Exp Hematol 23:918AGoogle Scholar
  156. 156.
    Eck SL, Perkins ND, Carr DP, Nabel GJ (1993) Inhibition of phorbol ester-induced cellular adhesion by competitive binding of NF-κB in vivo. Mol Cell Biol 13:6530–6536Google Scholar
  157. 157.
    Ledebur HC, Parks TP (1995) Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. J Biol Chem 270:933–943Google Scholar
  158. 158.
    Kunsch C, Ruben SM, Rosen CA (1992) Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol Cell Biol 12:4412–4421Google Scholar
  159. 159.
    Grimm S, Baeuerle PA (1993) The inducible transcription factor NF-κB: structure-function relationship of its protein subunits. Biochem J 290:297–308Google Scholar
  160. 160.
    Parry GCN, Mackman N (1994) A set on inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers. J Biol Chem 269:20823–20825Google Scholar
  161. 161.
    Stein B, Baldwin AS Jr, Ballard DW, Greene WC, Angel P, Herlich P (1993) Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO 12:3879–3891Google Scholar
  162. 162.
    Stein B, Cogswell PC, Baldwin AS Jr (1993) Functional and physical associations between NFKB and C/EBP family members. Mol Cel Biol 13:3964–3974Google Scholar
  163. 163.
    Perkins ND, Edwards NL, Duckett CS, Agranoff AB, Schmidt RM, Nabel GJ (1993) A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO 12:3551–3558Google Scholar
  164. 164.
    Ray A, Prefontaine KE (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 91:752–756Google Scholar
  165. 165.
    Caldenhoven E, Liden J, Wissink S, van de Stolpe A, Raaijmakers J, Koenderman L, Okret S, Gustafsson JA, van der Saag PT (1995) Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrin 9:401–412Google Scholar
  166. 166.
    Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin Jr AS (1995) Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 15:943–953Google Scholar
  167. 167.
    Juan TSC, Wilson DR, Wilde MD, Darlington GJ (1993) Participation of the transcription factor C/EBPδ in the acutephase regulation of the human gene for complement component C3. Proc Natl Acad Sci USA 90:2584–2588Google Scholar
  168. 168.
    Ohh M, Smoith CA, Carpenito C, Takei F (1994) Regulation of intercellular adhesion molecule-1 gene expression involves multiple mRNA stabilisation mechanisms: effects of interferon γ and phorbol myristate acatate. Blood 84:2632–2639Google Scholar
  169. 169.
    Ohh M, Takei F (1994) Interferon-γ and phorbol myristate acetate-responsive elements involved in intercellular adhesion molecule-1 mRNA stabilization. J Biol Chem 269:30117–30120Google Scholar
  170. 170.
    Zimmerman BJ, Holt JW, Paulson JC, Anderson DC, Miyasaka M, Tamatani T, Todd III RF, Rusche JR, Granger DN (1994) Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. Am J Physiol 266:H847-H853Google Scholar
  171. 171.
    Arnould T, Michiels C, Remacle J (1993) Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. Am J Physiol 264:C1102-C1110Google Scholar
  172. 172.
    Fine JS, Kruisbeek AM (1991) The role of LFA-l/ICAM-1 interactions during murine T lymphocyte development. J Immunol 147:2852–2859Google Scholar
  173. 173.
    Geissler D, Gaggl S, Most J, Greil R, Herold M, Dietrich M (1990) A monoclonal antibody directed against the human intercellular adhesion molecule (ICAM-1) modulates the release of tumor necrosis factor-α, interferon-γ and interleukin 1. Eur J Immunol 20:2591–2596Google Scholar
  174. 174.
    Rothlein R, Kishimoto TK, Mainolfi E (1993) Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes. J Immunol 152:2488–2495Google Scholar
  175. 175.
    Durieu-Trautmann O, Chaverot N, Cazauban S, Donny Strosberg A, Couraud PO (1994) Intercellular adhesion molecule-1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. J Biol Chem 269:12536–12540PubMedGoogle Scholar
  176. 176.
    Horssen van M, Loman S, Rijkers GT, Boom SE, Bloem AC (1995) Co-ligation of ICAM-1 (CD54) and membrane IgM negatively affects B cell receptor signaling. Eur J Immunol 25:154–158Google Scholar
  177. 177.
    Arroyo AG, Campanero MR, Sánchez-Mateos P, Zapata JM, Ursa A, del Pozo MA, Sánchez-Madrid F (1994) Induction of tyrosine phosphrylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. J Cell Biol 126:1277–1286Google Scholar
  178. 178.
    Campanero MR, Sánchez-Mateos P, del Pozo MA, Sánchez-Madrid F (1994) ICAM-3 regulates lymphocyte morphology and integrin-mediated T cell interaction with endothelial cell and extracellular matrix ligands. J Cell Biol 127:867–878Google Scholar
  179. 179.
    Juan M, Viñas O, Pino-Otín MR, Places L, Martínez-Cáceres E, Barceló JJ, Miralles A, Vilella R, Fuente MA de la, Vives J, Yagüe J, Gayá A (1994) CD50 (Intercellular adhesion molecule-3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line. J Exp Med 179:1747–1756Google Scholar
  180. 180.
    Fischer H, Gjörloff A, Hedlund G, Hedman H, Lundgren E, Kalland T, Sjögren HO, Dohlsten M (1992) Stimulation of human naive and memory T helper cells with bacterial superantigen. J Immunol 148:1993–1998Google Scholar
  181. 181.
    Damle NK, Klussman K, Linsley PS, Aruffo A (1992) Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigenprimed CD4+ T lymphocytes. J Immunol 148:1985–1992Google Scholar
  182. 182.
    Altmann DM, Hogg N, Trowsdale J, Wilkinson D (1989) Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells. Nature 338:512–514Google Scholar
  183. 183.
    Maio M, Tessitori G, Pinto A, Temponi M, Colombatti A, Ferrone S (1989) Differential role of distinct determinants of intercellular adhesion molecule-1 in immunologie phenomena. J Immunol 143:181–188Google Scholar
  184. 184.
    Makgoba MW, Sanders ME, Ginther-Luce GE, Dustin ML, Springer TA, Clark EA, Mannoni P, Shaw S (1988) ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature 331:86–88Google Scholar
  185. 185.
    Vanky F, Wang P, Patarroyo M, Klein E (1990) Expression of the adhesion molecule ICAM-1 and major histocompatibility complex class I antigens on human tumor cells is required for their interaction with autologous lymphocytes in vitro. Cancer Immunol Immunother 31:19–27Google Scholar
  186. 186.
    Jansen JH, van der Harst D, Wientjens GJHM, Kooy-Winkelaar YMC, Brand A, Willemze R, Kluin-Nelemans HC (1992) Induction of CD11 a/leukocyte function antigen-1 and CD54/intercellular adhesion molecule-1 on hairy cell leukemia cells is accompanied by enhanced susceptibility to T-cell but not lymphokine-activated killer-cell cytotoxity. Blood 80:478–483Google Scholar
  187. 187.
    Ybarrondo B, O'Rourke AM, Brian AA, Mescher MF (1994) Contribution of lymphocyte function-associated-1/intercellular adhesion molecule-1 binding to the adhesion/signaling cascade of cytotoxic T lymphocyte activation. J Exp Med 179:359–363Google Scholar
  188. 188.
    Dustin ML, Springer TA (1988) Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 107:321–331Google Scholar
  189. 189.
    Muller WA, Weigl SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178:449–460Google Scholar
  190. 190.
    Muller WA (1995) The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo. J Leukoc Biol 57:523–528Google Scholar
  191. 191.
    Chiang MY, Chan H, Zounes MA, Freier SM, Lima WF, Bennett CF (1991) Antisense oligonucleotides inhibit inercellular adhesion molecule-1 expression by two distinct mechanisms. J Biol Chem 266:18162–18171Google Scholar
  192. 192.
    Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Rudloff HE, Schmalstieg FC, Anderson DC (1988) Recognition of an endothelial determinant for CD18-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 82:1746–1756Google Scholar
  193. 193.
    Oppenheimer-Marks N, Davis LS, Tompkins Bogue D, Ramberg J, Lipsky PE (1991) Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes. J Immunol 147:2913–2921Google Scholar
  194. 194.
    Nawroth PP, Stern DM (1986) Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 163:740–745Google Scholar
  195. 195.
    Fan ST, Brian AA, Lollo BA, Mackman N, Shen NL, Edgington TS (1993) CD11a/CD18 (LFA-1) integrin engagement enhances biosynthesis of early cytokines by activated T cells. Cell Immunol 148:48–59Google Scholar
  196. 196.
    Fan ST, Edgington TS (1993) Integrin regulation of leukocyte inflammatory functions. J Immunol 150:2972–2980Google Scholar
  197. 197.
    Lukacs NW, Strieter RM, Einer VM, Evanoff HL, Burdick MM, Kunkel SL (1994) Intercellular adhesion molecule-1 mediates the expression of monocyte-derived MIP-lα during monocyte-endothelial cell interactions. Blood 83:1174–1178Google Scholar
  198. 198.
    Lord KA, Hoffman-Liebermann B, Liebermann DA (1990) Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants. Oncogene 5:387–396Google Scholar
  199. 199.
    Gordon MY, Clarke D, Atkinson J, Greaves MF (1990) Hemopoietic progenitor cell binding to the stromal microenvironment in vitro. Exp Hematol 18:837–842Google Scholar
  200. 200.
    Avraham H, Cowley S, Chi SY, Jiang S, Groopman JE (1993) Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J Clin Invest 91:2378–2384Google Scholar
  201. 201.
    Kurachi T, Morita I, Murota SI (1993) Involvement of adhesion molecules LFA-1 and ICAM-1 in osteoclast development. Biochim Biophys Acta 1178:259–266Google Scholar
  202. 202.
    Koopman G, Keehnen RMJ, Lindhout E, Newman W, Shimizu Y, van Seventer GA, de Groot C, Pals ST (1994) Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. J Immunol 152:3760–3767Google Scholar
  203. 203.
    Fougerolles AR de, Stacker SA, Schwarting R, Springer TA (1991) Characterization of ICAM-2 and evidence for a third counter receptor for LFA-1. J Exp Med 174:253–267Google Scholar
  204. 204.
    Tsukada N, Matsuda M, Miyagi K, Yanagisawa N (1993) Increased levels of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis. Neurology 43:2679–2682Google Scholar
  205. 205.
    Chihara J, Yamamoto T, Kurachi D, Nakajima S (1994) Soluble ICAM-1 in sputum of patients with bronchial asthma. Lancet 343:1108Google Scholar
  206. 206.
    Rothlein R, Mainolfi EA, Czajkowski, Marlin SD (1991) A form of circulating ICAM-1 in human serum. J Immunol 147:3788–3793Google Scholar
  207. 207.
    Becker JC, Dummer R, Hartmann AA, Burg G, Schmidt RE (1991) Shedding of ICAM-1 from human melanoma cell lines induced by IFN-γ and tumor necrosis factor-α. J Immunol 147:4398–4401Google Scholar
  208. 208.
    Budnik A, Trefzer U, Parlow F, Grewe M, Kapp A, Schöpf E, Krutmann J (1992) Human epidermal keratinocytes are a source of soluble ICAM-1 molecules. Exp Dermatol 1:27–30Google Scholar
  209. 209.
    Leeuwenberg JFM, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme TMAA, Ahern TJ, Buurman WA (1992) E-Selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology 77:543–549Google Scholar
  210. 210.
    Pigott R, Dillon LP, Hemingway IH, Gearing AJH (1992) Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun 187:584–589Google Scholar
  211. 211.
    Thomson AW, Satoh S, Nüssler AK, Tamura K, Woo J, Gavaler J, Thiel DH van (1994) Circulating intercellular adhesion molecule-1 (ICAM-1) in autoimmune liver disease and evidence for the production of ICAM-1 by cytokine-stimulated human hepatocytes. Clin Exp Immunol 95:83–90Google Scholar
  212. 212.
    Seth R, Raymond FD, Makgoba MW (1991) Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 338, 83–84Google Scholar
  213. 213.
    Cobb RR, Dubins JS, Warner J, Molony L (1992) Functional expression of soluble ICAM-1 by baculovirus-infected Sf9 cells. Biochem Biophys Res Commun 185:1022–1033Google Scholar
  214. 214.
    Welder CA, Lee DHS, Takei F (1993) Inhibition of cell adhesion by microspheres coated with recombinant soluble intercellular adhesion molecule-1. J Immunol 150:2203–2210Google Scholar
  215. 215.
    Crump CE, Arruda E, Hayden FG (1993) In vitro inhibitory activity of soluble ICAM-1 for the numbered serotypes of human rhinovirus. Antiviral Chem Chemother 4:323–327Google Scholar
  216. 216.
    Seventer GA van, Shimizu Y, Horgan KJ, Shaw S (1990) The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J Immunol 144:4579–4586Google Scholar
  217. 217.
    Banks RE, Gearing AJH, Hemingway IK, Norfolk DR, Perren TJ, Selby PJ (1993) Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies. Br J Cancer 68:122–124Google Scholar
  218. 218.
    Hvidd L, Theander TG, Elhassan IM, Jensen JB (1993) Increased plasma levels of soluble ICAM-1 and ELAM-1 (Eselectin) during acute plasmodium falciparum malaria. Immunol Letters 36:51–58Google Scholar
  219. 219.
    Clark WM, Coull BM, Briley DP, Mainolfi E, Rothlein R (1993) Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. J Neuroimmunol 44:123–126Google Scholar
  220. 220.
    Gearing AJH, Hemingway I, Pigott R, Hughes J, Rees AJ, Cashman SJ (1992) Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann NY Acad Sci 667:324–331Google Scholar
  221. 221.
    Kageshita T, Yoshii A, Kimura T, Kuriya N, Ono T, Tsujisaki M, Imai K, Ferrone S (1993) Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma. Cancer Res 53:4927–4932Google Scholar
  222. 222.
    Furukawa S, Motohashi T, Matsubara T, Imai K, Okomura K, Yabuta K (1993) Soluble ICAM-1 levels in serum during acute infectious mononucleosis. Scand J Infect Dis 25:249–252Google Scholar
  223. 223.
    Wenisch C, Varijanonta S, Looareesuwan S, Graninger W, Pichler R, Wernsdorfer W (1994) Soluble intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and tumor necrosis factor receptor (55kDA TNF-R) on patients with acute Plasmodium falciparum malaria. Clin Immunol Immunopathol 71:344–348Google Scholar
  224. 224.
    Zöhrens G, Armbrust T, Pirzer U, Meyer zum Büschenfelde KH, Ramadori G (1993) Intercellular adhesion molecule-1 concentration in sera of patients with acute and chronic liver disease: relationship to disease activity and cirrhosis. Hepatology 18:798–802Google Scholar
  225. 225.
    Shijubo N, Imai K, Shigehara K, Honda Y, Koba H, Tsujisaki M, Hinoda Y, Yachi A, Ohmichi M, Hiraga Y, Abe S (1994) Soluble intercellular adhesion molecule-1 (ICAM-1) in sera and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Clin Exp Immunol 95:156–161Google Scholar
  226. 226.
    Pforte A, Schiessler A, Gais P, van Kress S, Beer B, Riethmüller G, Ziegler-Heitbrock HWL (1993) Expression of the adhesion molecule ICAM-1 on alveolar macrophages and in serum in extrinsic allergic alveolitis. Respiration 60:221–226Google Scholar
  227. 227.
    Sfikakis PP, Charalambopoulos D, Vayiopoulos G, Oglesby R, Sfikakis P, Tsokos GC (1994) Increased levels of intercellular adhesion molecule-1 in the serum of patients with systemic lupus erythematosus. Clin Exp Rheumatol 12:5–9Google Scholar
  228. 228.
    Tsukada N, Miyagi K, Matsuda M, Yanagisawa N (1993) Increased levels of circulating intercellular adhesion molecule-1 in multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy. Ann Neurol 33:646–649Google Scholar
  229. 229.
    Kobayashi T, Hashimoto S, Imai K, Amemiya E, Yamaguchi M, Yachi A, Horie T (1994) Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma. Clin Exp Immunol 96:110–115Google Scholar
  230. 230.
    Montefort S, Lai CKW, Kapahi P, Leung J, Lai KM, Chan HS, Haskard DO, Howarth PH, Holgate ST (1994) Circulating adhesion molecules in asthma. Am J Resp Crit Med 149:1149–1152Google Scholar
  231. 231.
    Dalhoff K, Bonnet S, Braun J, Kreft B, Wiessmann KJ (1993) Intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of mononuclear cell alveolitis in pulmonary sarcoidosis. Thorax 48:1140–1144Google Scholar
  232. 232.
    Riise GC, Larsson S, Lofdahl EG, Andersson BA (1994) Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis. Eur Resp J. 7:1673–1677Google Scholar
  233. 233.
    Williams IR, Kupper TS (1994) Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice. Proc Natl Acad Sci USA 91:9710–9714Google Scholar
  234. 234.
    Johnson JP (1991) The role of ICAM-1 in tumor development. Integrins and ICAM-1 in immune responses. Chem Immuno50:143–163Google Scholar
  235. 235.
    Pandolfi F, Trentin L, Boyle LA, Stamenkovic I, Randolph Byers H, Colvin RB, Kurnick JT (1991) Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor-infiltrating lymphocytes. Cancer 69:1165–1173Google Scholar
  236. 236.
    Padros MR, Noli MI, Fainboim L (1992) Expression of ICAM-1 (CD54) on normal and leukaemic B cells: implication for the mixed lymphocyte reaction. Clin Exp Immunol 88:329–334Google Scholar
  237. 237.
    Raspadori D, Lauria F, Ventura MA, Rondelli D, Tura S (1993) Expression of adhesion molecules on acute leukemic blast cells and sensitivity to normal LAK activity. Ann Hematol 67:213–216Google Scholar
  238. 238.
    Renkonen R, Paavonen T, Nortamo P, Gahmberg CG (1992) Expression of endothelial adhesion molecules in vivo. Am J Pathol 140:763–767Google Scholar
  239. 239.
    Greve JM, Forte CP, Marlor CW, Meyer AM, Hoover-Litty H, Wunderlich D, McClelland A (1991) Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1. J Virol 65:6015–6023Google Scholar
  240. 240.
    Johnson JP, Stade BG, Hupke U, Holzmann B, Riethmüller G (1988) The melanoma progression-associated antigen P3.58 is identical to the intercellular adhesion molecule, ICAM-1. Immunobiol 178:275–284Google Scholar
  241. 241.
    Johnson JP, Stade BG, Holzmann B, Schwäble W and Riethmüller G (1989) De novo expression of intercellular-adhesion molecule-1 in melanoma correlates with increased risk of metastasis. Proc Natl Acad Sci USA 86:641–644Google Scholar
  242. 242.
    Giavazzi R, Chirivi RGS, Garofalo A, Rambaldi A, Hemingway I, Pigott R, Gearing AJH (1992) Soluble intercellular adhesion molecule 1 is released by human melanoma cells and is associated with tumor growth in nude mice. Cancer Res 52:2628–2630Google Scholar
  243. 243.
    Altomonte M, Gloghini A, Bertola G, Gasparollo A, Carbone A, Ferrone S, Maio M (1993) Differential expression of cell adhesion molecules CD54/CD11a and CD58/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells. Cancer Res 53:3343–3348Google Scholar
  244. 244.
    Becker JC, Termeer C, Schmidt RE, Bröcker EB (1993) Soluble intercellular adhesion molecule-1 inhibits MHC-restricted specific T cell/tumor interaction. J Immunol 151:7224–7232Google Scholar
  245. 245.
    Maio M, del Vecchio L (1992) Expression and functional role of CD54/intercellular adhesion molecule-1 (ICAM-1) on human blood cells. Leukemia and Lymphoma 8:23–33Google Scholar
  246. 246.
    Lu D, Thompson JD, Gorski GK, Rice NR, Mayer MG, Yunis JJ (1991) Alterations at the rel locus in human lymphoma. Oncogene 6:1235–1241Google Scholar
  247. 247.
    Neri A, Chang CC, Lombardi L, Salina M, Corradini P, Maiolo AT, Chaganti RSK, Dalla-Favera R (1991) B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10 homologous to NF-κB p50. Cell 67:1075–1087Google Scholar
  248. 248.
    Kerr LD, Duckett CD, Wamsley P, Zhang Q, Chiao P, Nabel G, McKeithan TW, Baeuerle PA, Verma IM (1992) The proto-oncogene BCL-3 encodes an IκB protein. Genes Devel 6:2352–2363Google Scholar
  249. 249.
    Fracchiolla NS, Lombardi L, Salina M, Migliazza A, Baldini L, Berti E, Cro L, Polli E, Maiolo AT, Neri A (1991) Structural alterations of the NF-κB transcription factor lyt-10 in lymphocytic malignancies. Oncogene 8:2839–2845Google Scholar
  250. 250.
    Archimbaud E, Thomas X, Campos L, Magaud JP, Doré JF, Fiere D (1992) Expression of surface adhesion molecules CD54 (ICAM-1) and CD58 (LFA-3) in adult acute leukemia: Relationship with initial characteristics and prognosis. Leukemia 6:265–271Google Scholar
  251. 251.
    Grignani F, Fagioli M, Alkalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Coco F, Grignani F, Pelicci PG (1994) Acute promyelocyte leukemia: from genetics to treatment. Blood 83:10–25PubMedGoogle Scholar
  252. 252.
    Möller P, Henne C, Leithäuser F, Eichelmann A, Schmidt A, Brüderlein S, Dhein J, Krammer PH (1993) Coregulation of the APO-1 antigen with intercullular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicular center and mediastinal B-cell lymphomas. Blood 81:2067–2075Google Scholar
  253. 253.
    Takeuchi H, Katayama I (1993) Surface phenotype and adhesion activity of B-cell chronic lymphoid leukemias. Leukemia and lymphoma 10:209–216Google Scholar
  254. 254.
    Kimby E, Rincón J, Patarroyo M, Mellstedt H (1994) Expression of adhesion molecules CD11/CD18 (Leu-CAMs, β2-integrins), CD54 (ICAM-1) and CD58 (LFA-3) in B-chronic lymphocytic leukemia. Leuk Lymphoma 13:297–306Google Scholar
  255. 255.
    Riet I van, Waele M de, Remels L, Lacor P, Schots R, Camp B van (1991) Expression of cytoadhesion molecules (CD56, CD54, CD18 and CD29) by myeloma plasma cells. Br J Hematol 79:421–427Google Scholar
  256. 256.
    Riet I van, Camp B van (1993) The involvement of adhesion molecules in the biology of multiple myeloma. Leukemia and Lymphoma 9:441–452Google Scholar
  257. 257.
    Marotta G, Zagonel V, Pinto A (1993) Induction of LFA-1/CD11a and ICAM-1/CD54 adhesion molecules on neoplastic B cells during in vivo treatment of chronic lymphocytic leukemia with interferon-α2. Blood 81:267–69Google Scholar
  258. 258.
    Nozawa Y, Yamaguchi Y, Tominaga K, Hojo H, Abe M, Wakasa H (1993) Expression of leukocyte adhesion molecules (ICAM-1/LFA-1) related to clinical behaviour in B cell lymphomas. Hematol Oncol 10:189–194Google Scholar
  259. 259.
    Stauder R, Greil R, Schultz TF, Thaler J, Gattringer C, Radaskiewicz T, Dierich MP, Huber H (1989) Expression of leucocyte function-associated antigen-1 and 7F7-antigen, an adhesion molecule related to intercellular adhesion molecule-1 (ICAM-1) in non-Hodgkin lymphomas and leukaemias; possible influence on growth pattern and leukaemic behaviour. Clin exp Immunol 77:234–238Google Scholar
  260. 260.
    Petrasch S, Kosco M, Schmitz J, Wacker HH, Brittinger G (1992) Follicular dendritic cells on non-Hodgkin-lymphoma express adhesion molecules complementary to ligands on neoplastic B-cells. Br J Hematol 82:695–700Google Scholar
  261. 261.
    Gregory CD, Murray RJ, Edwards CF, Rickinson AB (1988) Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance. J Exper Med 167:1811–1824Google Scholar
  262. 262.
    Rincón J, Prieto J, Patarroyo M (1992) Expression of integrins and other adhesion molecules in Epstein-Barr virustransformed B lymphoblastoid cells and Burkitt's lymphoma cells. Int J Cancer 51:452–458Google Scholar
  263. 263.
    Billaud M, Calender A, Seigneurin JM, Lenoir GM (1987) LFA-1, LFA-3, and ICAM-1 expression in Burkitt's lymphoma. Lancet: 1327–1328Google Scholar
  264. 264.
    Bashir R, Coakham H, Hochberg F (1992) Expression of LFA-1/ICAM-1 in CNS lymphomas: possible mechanism for lymphoma homing into the brain. J Neuro-oncology 12:103–110Google Scholar
  265. 265.
    Pizzolo G, Vinante F, Nadali G, Ricetti MM, Morosato L, Marrocchella R, Vincenzi C, Semenzato G, Chilosi M (1993) ICAM-1 tissue overexpression associated with increased serum levels of its soluble form in Hodgkin's disease. Br J Hematol 84:161–162Google Scholar
  266. 266.
    Fukudome K, Furuse M, Fukuhara N, Orita S, Imai T, Takagi S, Nagira M, Hinuma Y, Yoshie O (1992) Strong induction of ICAM-1 in human T cells transformed by human T-cell-leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell-leukemia-derived cell lines. Int J Cancer 52:418–427Google Scholar
  267. 267.
    Leff AR, Hamann KJ, Wegner CD (1991) Inflammation and cell-cell interactions in airway responsiveness. Am J Physiol 260:L189-L206Google Scholar
  268. 268.
    Walker C, Rihs S, Braun RK, Betz S, Bruijnzeel PLB (1993) Increased expression of CD11b and functional changes in eosinophils after migration across endothelial cell monolayers. J Immunol 150:4061–4071Google Scholar
  269. 269.
    Lasalle P, Gosset P, Delneste Y, Tsicopoulos A, Capron A, Joseph M, Tonnell AB (1993) Modulation of adhesion molecule expression on endothelial cells during the late asthmatic reaction: role of macrophage-derived tumor necrosis factor-α. Clin Exp Immunol 94:105–110Google Scholar
  270. 270.
    Lemanske RF Jr, Dick EC, Swenson CA, Vrtis FR, Busse WW (1989) Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest 83:1–10Google Scholar
  271. 271.
    Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R (1990) Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science 247:456–459Google Scholar
  272. 272.
    Aoki S, Imai K, Yachi A (1993) Soluble intercellular adhesion molecule-1 (ICAM-1) antigen in patients with rheumatoid arthritis. Scand J Immunol 38:485–490Google Scholar
  273. 273.
    Argenbright LW, Barton RW (1992) Interactions of leukocyte integrins with intercellular adhesion molecule-1 in the production of inflammatory vascular injury in vivo. J Clin Invest 89:259–272Google Scholar
  274. 274.
    Melis M, Gjomarkaj M, Pace E, Malizia G, Spatafora M (1991) Increased expression of leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by alveolar macrophages of patients with pulmonary sarcoidosis. Chest 100:910–916Google Scholar
  275. 275.
    Dinther-Janssen AHCM van, van Maarsseveen TCMT, Eckert H, Newman W, Meijer CJLM (1993) Identical expression of ELAM-1, VCAM-1, and ICAM-1 in sarcoidosis and usual interstitial pneumonitis. J Pathol 170:157–164Google Scholar
  276. 276.
    Wuthrich RP, Jevnikar AM, Takei F, Glimcher LH, Kelly VE (1990) Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis. Am J Pathol 136:441–450Google Scholar
  277. 277.
    Kawasaki K, Yaoita E, Yamamoto T, Tamatani T, Miyasaka M, Kihara I (1993) Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis. J Immunol 150:1074–1083Google Scholar
  278. 278.
    Hill PA, Lan HY, Nikolic-Paterson DJ, Atkins RC (1994) ICAM-1 directs migration and localization of interstitial leukocytes in experimental glomerulonephritis. Kidney Int 45:32–42Google Scholar
  279. 279.
    Chu CM, Liaw YF (1993) Coexpression of intercellular adhesion molecule-1 and class I major histocompatibility complex antigens on hepatocyte membrane in chronic viral hepatitis. J Clin Pathol 46:1004–1008Google Scholar
  280. 280.
    Garcia-Monzon C, Garcia-Buey L, Carcia-Sanchez A, Pajares JM, Moreno-Otero R (1993) Down-regulation of intercellular adhesion molecule 1 on hepatocytes in viral chronic hepatitis treated with Interferon α-2b. Gastroenterology 105:462–469Google Scholar
  281. 281.
    Horike N, Onji M, Kumon I, Kanaoka M, Michitaka K, Ohta Y (1993) Intercellular adhesion molecule-1 expression on the hepatocyte membrane of patients with chronic hepatitis B and C. Liver 13:10–14Google Scholar
  282. 282.
    Lim AG, Jazrawi RP, Ahmed HA, Levy JH, Zuin M, Douds AC, Maxwell JD, Northfield TC (1994) Soluble intercellular adhesion molecule-1 in primary biliary cirrhosis: relationship with disease stage, immune activity and cholestasis. Hepatology 20:882–888Google Scholar
  283. 283.
    Mosnier JF, Scoazec JY, Marcellin P, Degott C, Benhamou JP, Feldmann G (1994) Expression of cytokine-dependent immune adhesion molecules by hepatocytes and bile duct cells in chronic hepatitis C. Gastroenterol 107:1457–1468Google Scholar
  284. 284.
    Tipping PG, Hancock WW (1993) Production of tumor necrosis factor and interleukin-1 by macrophages from human atheromateus plaques. Am J. Pathol 142:1721–1728Google Scholar
  285. 285.
    Frostegard J, Wu R, Haegerstrand A, Patarroyo M, Lefvert AK, Nilsson J (1993) Mononuclear leukocytes exposed to oxidized low density lipoprotein secrete a factor that stimulates endothelial cells to express adhesion molecules. Atherosclerosis 103:213–219Google Scholar
  286. 286.
    Bini A, Fenoglio Jr JJ, Mesa-Tejada R, Kudryk B, Kaplan KL (1989) Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Arteriosclerosis 9:109–121Google Scholar
  287. 287.
    Poston RN, Haskard DO, Coucher JR, Gall NP, Johnson-Tidey RR (1992) Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol 140:665–673Google Scholar
  288. 288.
    Wal van der AC, Das PK, Tigges AJ, Becker AE (1992) Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am J Pathol 141:1427–1433PubMedGoogle Scholar
  289. 289.
    Davies MJ, Gordon JL, Gearing AHJ, Pigott R, Woolf N, Katz D, Kyriakopoulos A (1993) The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selection in human atherosclerosis. J Pathol 171:223–229Google Scholar
  290. 290.
    Wood KM, Cadogan MD, Ramshaw AL, Parums DV (1993) The distribution of adhesion molecules in huan atherosclerosis. Histopathology 22:437–444Google Scholar
  291. 291.
    Ross R, (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801–809Google Scholar
  292. 292.
    Kurose I, Kubes P, Wolf R, Anderson DC, Paulson J, Miyasaka M, Granger DN (1993) Inhibition of nitric oxide production. Circ Res 73:164–171Google Scholar
  293. 293.
    Jerome SN, Doré M, Paulson JC, Smith CW, Korthuis RJ (1994) P-selectin and ICAM-1-dependent adherence reactions: role in the genesis of postischemic no-reflow. Am J Physiol 266:H1316-H1321Google Scholar
  294. 294.
    Shreeniwas R, Koga S, Karakurum M, Pinsky D, Kaiser E, Brett J, Wolitzky BA, Norton C, Plocinski J, Burns DK, Goldstein A, Stern D (1992) Hypoxia-mediated induction of endothelial cell interleukin-lα. J Clin Invest 90:2333–2339Google Scholar
  295. 295.
    Nolte D, Hecht R, Schmid P, Botzlar A, Menger MD, Neumueller C, Sinowatz F, Vestweber D, Messmer K (1994) Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of balb/c mice. Am J Physiol 267:H1320-H1328Google Scholar
  296. 296.
    Deventer SJH van, Büller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A (1990) Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 76:2520–2526Google Scholar
  297. 297.
    Lo SK, Everitt J, Malik AB (1992) Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms. J Clin Invest 89:981–988Google Scholar
  298. 298.
    Singer KH, Tuck DT, Sampson HA, Hall RP (1989) Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses. J Invest Dermatol 92:746–750Google Scholar
  299. 299.
    Vejlsgaard GL, Ralfkiaer E, Avnstorp C, Czajkowski M, Marlin SD, Rothlein R (1989) Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas. J Am Acad Dermatol 20:782–790Google Scholar
  300. 300.
    Sobel RA, Mitchell ME, Fondren G (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 136:1309–1316Google Scholar
  301. 301.
    Akiyama H, Kawamata T, Yamada T, Tooyama I, Ishii T, McGeer PL (1993) Expression of intercellular adhesion molecule (ICAM)-l by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders. Acta Neuropathol 85:628–634Google Scholar
  302. 302.
    Zielasek J, Archelos JJ, Toyka KV, Hartung HP (1993) Expression of intercellular adhesion molecule-1 on rat microglial cells. Neurosci Lett 153:136–13Google Scholar
  303. 303.
    Tsukada N, Matsuda M, Miyagi K, Yanagisawa N (1994) In vitro intercellular adhesion molecule-1 expression on brain endothelial cells in multiple sclerosis. J Neuroimmunol 49:181–187Google Scholar
  304. 304.
    Verbeek MM, Otte-Höller I, Westphal JR, Wesseling P, Ruiter DJ, de Waal RMW (1994) Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol 144:104–116Google Scholar
  305. 305.
    Washington R, Burton J, Todd III RF, Newman W, Dragovic L, Dore-Duffy P (1994) Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from patients with multiple sclerosis. Ann Neurol 35:89–97Google Scholar
  306. 306.
    Isobe M, Yagita H, Okumura K, Ihara A (1992) Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255:1125–1126Google Scholar
  307. 307.
    Haug GE, Colvin RB, Delmonico FL, Auchincloss H Jr, To-Ikoff-Rubin N, Preffer FI, Rothlein R, Norris S, Scharschmidt L, Cosimi AB (1993) A phase I trial of immunosuppression with anti-ICAM-1 (CD54) mAb in renal allograft recipients. Transplantation 55:766–773Google Scholar
  308. 308.
    Norton J, Sloane JP (1994) A prospective study of cellular and immunologie changes in skin of allogeneic bone marrow recipients. Am J Clin Pathol 101:597–602Google Scholar
  309. 309.
    Bennett CF, Condon TP, Grimm S, Chan H, Chiang MY (1994) Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J Immunol 152:3530–3540Google Scholar
  310. 310.
    O Roep B, Heidenthal E, de Vries RRP, Kolb H, Martin S (1994) Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus. Lancet 343:1590–1592Google Scholar
  311. 311.
    Archelos JJ, Maurer M, Jung S, Toyka K, Hartung HP (1993) Suppression of experimental allergie neuritis by an antibody to the intercellular adhesion molecule ICAM-1. Brain 116:1043–1058Google Scholar
  312. 312.
    Seko Y, Matsuda H, Kato K, Hashimoto Y, Yagita H, Okumura K, Yazaki Y (1993) Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3. J Clin Invest 91:1327–1336Google Scholar
  313. 313.
    Fischer A (1991) Anti-LFA-1 antibody as immunosuppressive reagent in transplantation, in: Hogg N (ed) Integrins and ICAM-1 in immune responses. Chem Immunol 50:89–97Google Scholar
  314. 314.
    Balkwill F (1993) Improving on the formula. Nature 361:206–207Google Scholar
  315. 315.
    Huang YW, Burrows FJ, Vitetta ES (1993) Cytotoxicity of a novel anti-ICAM-1 immunotoxin on human myeloma cell lines. Hybridoma 12:661–675Google Scholar
  316. 316.
    Bloemen PGM, Henricks PAJ, Vanbloois L, van den Tweel MC, Bloem AC, Nijkamp FP, Crommelin DJA, Storm G (1995) Adhesion molecules: a new target for immunoliposome-mediated drug delivery. FEBS Lett 357:140–144Google Scholar
  317. 317.
    Puppo F, Brenci S, Scudeletti M, Lanza L, Bosco O, Indiveri F (1993) Elevated serum levels of circulating intercellular adhesion molecule-1 in HIV infection. AIDS 7:593–594Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • A. van de Stolpe
    • 1
  • P. T. van der Saag
    • 2
  1. 1.Department of HematologyUniversity Hospital NijmegenHB NijmegenThe Netherlands
  2. 2.Hubrecht LaboratoryNetherlands Institute of Developmental BiologyUtrechtThe Netherlands

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