Human Genetics

, Volume 94, Issue 4, pp 423–426

Parental origin of the extra chromosomes in polysomy X

  • C. A. Leal
  • John W. Belmont
  • Ron Nachtman
  • J. M. Cantu
  • C. Medina
Original Investigation

Abstract

Five polymorphic index markers were analyzed by polymerase chain reaction (PCR) to ascertain the parental origin of the extra X chromosomes in seven polysomic cases (one 49,XXXXX, three 49,XXXXY, two 48,XXXY, and one 48, XXYY). All four X chromosomes in 49, X polysomies were maternal in origin and the extra X chromosomes in 48 X polysomies were paternal. In each case the multiple X chromosomes were contributed by a single parent. Taken together with previously reported cases, these data support a single mechanism of sequential nondisjunction during either maternal or paternal gametogenesis as the cause of higher order sex chromosome polysomy.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • C. A. Leal
    • 1
  • John W. Belmont
    • 2
  • Ron Nachtman
    • 2
  • J. M. Cantu
    • 1
  • C. Medina
    • 1
  1. 1.División de GenéticaCentro de Investigación, Biomédica de Occidente, IMSSGuadalajara JalMexico
  2. 2.Institute for Molecular Genetics, Baylor College of MedicineHoustonUSA

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