Cancer Immunology, Immunotherapy

, Volume 15, Issue 2, pp 159–161 | Cite as

Effect of dichloromethylene diphosphonate (Cl2MDP) on immune function in breast cancer patients with bone metastases

  • Ritva Markkula
  • Heikki Repo
  • Marjatta Leirisalo
  • Carl Blomqvist
  • Inkeri Elomaa
Short Communication
Received:
Accepted:

Summary

Immune function was studied in normocalcemic breast cancer patients with bone metastases treated with either dichloromethylene diphosphonate (Cl2MDP) or placebo. The results showed no significant difference between the two patient groups. This suggests that Cl2MDP does not markedly impair the host's defense mechanisms, and in this respect can be safely used in the treatment of patients with resorptive bone disease.

Keywords

Breast Cancer Placebo Cancer Patient Cancer Research Patient Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Basten A (1981) The role of T cell subsets and Ia antigens in delayed-type hypersensitivity. Int Arch Allergy Appl Immunol [Suppl 1] 66:197Google Scholar
  2. 2.
    Bijvoet OLM, Frijlink WB, Jie K, van der Linden H, Meijer CJLM, Mulder H, van Paassen HC, Reitsma PH, te Velde J, de Vries E, Van der Wey JP (1980) APD in Paget's disease of bone. Role of mononuclear phagocyte system? Arthritis Rheum 23:1193Google Scholar
  3. 3.
    Boetcher DA, Leonard EJ (1974) Abnormal monocyte chemotactic response in cancer patients. J Natl Cancer Inst 52:1091Google Scholar
  4. 4.
    Carlsson HE, Hurvall B, Lindberg AA (1976) Enzyme-linked immunosorbent assay (ELISA) for titration of antibodies against Brucella abortus and Yersinia enterocolitica. Acta Pathol Microbiol Scand [C] 84:168Google Scholar
  5. 5.
    D'Amelio R, LeMoli S, Rossi P, Aiuti F (1980) Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method. Scand J Immunol 11:471Google Scholar
  6. 6.
    De Vries E, van der Wej JP, v. d. Veen CJP, van Paassen HC, Jager MJ, Sleeboom HP, Bijvoet OLM, Cats A (1982) In vitro effect of (3-amino-1-hydroxypropylidene)-1,1-biphosphonic acid (APD) on the function of mononuclear phagocytes in lymphocyte proliferation. Immunology 47:157Google Scholar
  7. 7.
    Editorial (1981) Diphosphonates: Aimed in a chemical sense. Lancet 2:1326Google Scholar
  8. 8.
    Fleisch H (1980) Experimental basis for the clinical use of diphosphonates in Paget's disease of bone. Arthritis Rheum 23:1162Google Scholar
  9. 9.
    Flora L (1979) Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis. Arthritis Rheum 22:340Google Scholar
  10. 10.
    Hausman MS, Brosman S, Snyderman R, Mickey MR, Fahey J (1975) Defective monocyte function in patients with genitourinary carcinoma. J Natl Cancer Inst 55:1047Google Scholar
  11. 11.
    Jacobs TP, Siris ES, Bilezikian JP, Baquiran DC, Shane E, Canfield RE (1981) Hypercalcemia of malignancy: Treatment with intravenous dichloromethylene diphosphonate. Ann Intern Med 94:312Google Scholar
  12. 12.
    Johnston CC Jr, Khairi MRA, Meunier PJ (1980) Use of etidronate (EHDP) in Paget's disease of bone. Arthritis Rheum 23:1172Google Scholar
  13. 13.
    Komissarenko SV, Zhuravskii NI, Karlova NP, Gulyi MF (1977) Inhibition of hypersensitivity of delayed and immediate types in guinea pigs by methylenediphosphonic acid. Byull Eksp Biol Med 84:1322Google Scholar
  14. 14.
    Repo H, Kostiala AAI, Kosunen TU (1978) Use of leucocyte migration under agarose to study spontaneous and directed locomotion of leucocytes. Immunology 35:539Google Scholar
  15. 15.
    Repo H, Jokipii AMM, Leirisalo M, Kosunen TU (1980) Leucocyte motility in the newborn: determination of spontaneous movement is essential in the in vitro assessment of neutrophil chemotaxis. Clin Exp Immunol 40:620Google Scholar
  16. 16.
    Repo H, Kostiala AAI, Kosunen TU (1980) Cellular hypersensitivity to tuberculin in BCG-revaccinated persons studied by skin reactivity, leucocyte migratioin inhibition and lymphocyte proliferation. Clin Exp Immunol 39:442Google Scholar
  17. 17.
    Russel RGG, Mühlbauer RC, Bisaz S, Williams DA, Fleisch H (1970) The influence of pyrophosphate, condensed phosphates, phosphonates, and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rats. Calcif Tissue Res 6:183Google Scholar
  18. 18.
    Ruutu P, Ruutu T, Vuopio P, Kosunen TU, de la Chapelle A (1977) Function of neutrophils in preleukemia. Scand J Haematol 18:317Google Scholar
  19. 19.
    Schuurman RKB, Gelfand EW, Dosch H-M (1980) Polyclonal activation of human lymphocytes in vitro. I. Characterization of the lymphocyte response to a T cell-independent B cell mitogen. J Immunol 125:820Google Scholar
  20. 20.
    Siris ES, Canfield RE, Jacobs TP, Baquiran DC (1980) Long-term therapy of Paget's disease of bone with EHDP. Arthritis Rheum 23:1177Google Scholar
  21. 21.
    Snyderman R, Seigler HF, Meadows L (1977) Abnormalities of monocyte chemotaxis in patients with melanoma: Effects of immunotherapy and tumor removal. J Natl Cancer Inst 58:37Google Scholar
  22. 22.
    Snyderman R, Meadows L, Holder W, Wells S Jr (1978) Abnormal monocyte chemotaxis in patients with breast cancer: Evidence for a tumor-mediated effect. J Natl Cancer Inst 60:737Google Scholar
  23. 23.
    Woodhouse NJY (1981) Paget's disease. Clin Rheum Dis 7:647Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Ritva Markkula
    • 1
  • Heikki Repo
    • 1
  • Marjatta Leirisalo
    • 1
  • Carl Blomqvist
    • 2
  • Inkeri Elomaa
    • 2
  1. 1.Department of Bacteriology and ImmunologyUniversity of HelsinkiHelsinki 29Finland
  2. 2.Department of Radiotherapy and OncologyHelsinki University Central HospitalHelsinkiFinland

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