Cancer Immunology, Immunotherapy

, Volume 9, Issue 1–2, pp 69–72 | Cite as

Treatment of carcinoma in situ of the bladder with BCG

A phase II trial
  • Alvaro Morales
Original Articles


Although carcinoma in situ conveys the idea of an early neoplasm, such lesions in the bladder mucosa commonly exhibit a very aggressive behavior and carry a grave prognosis. Seven patients with in situ carcinoma of the bladder have been treated with intravesical and systemic administration of Bacillus Calmette-Guérin. Elimination of tumor was documented by endoscopy, histology and cytology in five patients. These five patients have remained tumor-free for periods ranging between 12 and 33 months (mean: 22.6). This preliminary study indicates that regional and systemic immunotherapy is an alternative worth additional investigation in patients with carcinoma in situ of the bladder.


Carcinoma Cancer Research Aggressive Behavior Systemic Administration Additional Investigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Alvaro Morales
    • 1
  1. 1.Department of UrologyQueen's UniversityKingstonCanada

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