Cancer Immunology, Immunotherapy

, Volume 11, Issue 2, pp 93–96 | Cite as

Positive skin tests with autologous tumor cells of increased membrane viscosity

First report
  • Y. Skornick
  • E. Danciger
  • R. R. Rozin
  • M. Shinitzky
Original Articles

Summary

Skin tests were carried out with irradiated autologous tumor cells in patients with solid tumors (large-bowel carcinoma, gastric carcinoma, malignant melanoma, and breast cancer). With untreated cells, the skin reaction was negative or very weakly positive. A strong skin reaction, however, was elicited with cells of elevated membrane lipid microviscosity. This was induced by incorporation of cholesterol or, more effectively, by cholesterly hemisuccinate (CHS). A fair correlation was observed between the level of skin reaction with CHS-treated cells and the clinical stage of the tumor. It is suggested that rigidification of the cell membrane lipid layer exposes latent tumor-associated antigens, which enhances the cell-specific tumor immunogenicity. CHS-treated cells could therefore be of clinical value in active immunotherapy of human cancer.

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Copyright information

© Springer-Verlag GmbH & Co KG 1981

Authors and Affiliations

  • Y. Skornick
    • 1
  • E. Danciger
    • 2
  • R. R. Rozin
    • 1
  • M. Shinitzky
    • 2
  1. 1.Department of SurgeryRokach HospitalTel Aviv
  2. 2.Department of Membrane ResearchThe Weizmann Institute of ScienceRehovotIsrael

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