Human Genetics

, Volume 88, Issue 3, pp 356–356

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

  • N. Morral
  • E. Girbau
  • J. Zielenski
  • V. Nunes
  • T. Casals
  • L. -C. Tsui
  • X. Estivill
DNA Variants

Summary

We describe a polymorphic microsatellite (IVS17BCA) in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It consists of an 11 to 20 CA/GT dinucleotide repeat, located 424 bp from exon 17B.

References

  1. Morral N, Nunes V, Casals V, Estivill X (1991) CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover. Genomics 10:692–698Google Scholar
  2. Saiki RK, Gelfand DH, Stoffel S, Sharf SJ, Higuchi R, Horn GT, Erlich HA (1988) Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491PubMedGoogle Scholar
  3. Zielenski J, Rozmahel R, Bozon D, Kerem B-S, Grzelczak Z, Riordan JR, Rommens J, Tsui L-C (1991) Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Genomics 10:214–228Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • N. Morral
    • 1
  • E. Girbau
    • 1
  • J. Zielenski
    • 2
  • V. Nunes
    • 1
  • T. Casals
    • 1
  • L. -C. Tsui
    • 2
  • X. Estivill
    • 1
  1. 1.Molecular Genetics DepartmentInstitut de Recerca Oncològica, Hospital Duran i Reynals, L'Hospitalet de LlobregatBarcelonaSpain
  2. 2.Department of GeneticsThe Hospital for Sick ChildrenTorontoCanada

Personalised recommendations