European Journal of Clinical Pharmacology

, Volume 46, Issue 6, pp 523–526 | Cite as

Smoking and body weight influence the clearance of chlorpromazine

  • M. Chetty
  • R. Miller
  • S. V. Moodley


The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements from 31 patients.

A NONMEM analysis demonstrated that the clearance of CPZ depended on the patient's body weight. Cigarette smoking and cannabis smoking increased the clearance of CPZ. Chronic alcohol consumption and the concurrent use of anticholinergics did not appear to influence the clearance of CPZ significantly.

Key words

Chlorpromazine Schizophrenic patients population pharmacokinetics clearance cigarette smoking cannabis smoking 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • M. Chetty
    • 1
  • R. Miller
    • 1
  • S. V. Moodley
    • 2
  1. 1.Drug Studies UnitUniversity of Durban-WestvilleDurbanSouth Africa
  2. 2.Fort Napier HospitalPietermaritzburgSouth Africa

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