European Journal of Clinical Pharmacology

, Volume 46, Issue 1, pp 9–13

The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate

  • H. Knauf
  • W. Cawello
  • G. Schmidt
  • E. Mutschler
Originals

DOI: 10.1007/BF00195908

Cite this article as:
Knauf, H., Cawello, W., Schmidt, G. et al. Eur J Clin Pharmacol (1994) 46: 9. doi:10.1007/BF00195908

Abstract

The effect of the thiazide diuretic, bemetizide, on the excretion of Na+, K+, Cl, Ca2+, and Mg2+ in relation to the glomerular filtration rate (GFR) was studied in 17 subjects whose creatinine clearances ranged from 133 to 5 ml·min−1.

After a 2-day fluid and salt balanced control period, 25 mg bemetizide given orally induced natriuresis and kaliuresis which lasted for 24 h and were proportional to the GFR of the patients. The ratio of bemetizide-induced K+/Na+ excretion was always 0.17 irrespective of individual GFR. In renal failure, bemetizide increased the fractional Na+ excretion from 3% to about 10%. Kaliuresis was associated with magnesiuria, whereas bemetizide-induced calciuresis was insignificant. The thiazide reversibly lowered GFR in all subjects.

Key words

Bemetizide Salt excretion pattern Na+ K+ Cl Mg2+ Ca+ chronic renal failure renal haemodynamics 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H. Knauf
    • 1
  • W. Cawello
    • 2
  • G. Schmidt
    • 2
  • E. Mutschler
    • 3
  1. 1.Medizinische Klinik IHildesheimGermany
  2. 2.Abteilung Biomathematik und Medizinische Forschung, Schwarz Pharma AGMonheimGermany
  3. 3.Pharmakologisches Institut für NaturwissenschaftlerUniversität Frankfurt/MainGermany
  4. 4.Medizinische Klinik IHildesheimGermany

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